Styrene alters potassium endolymphatic concentration in a model of cultured utricle explants.

Toxicology in Vitro : an International Journal Published in Association with BIBRA
V TallandierB Pouyatos

Abstract

Despite well-documented neurotoxic and ototoxic properties, styrene remains commonly used in industry. Its effects on the cochlea have been extensively studied in animals, and epidemiological and animal evidence indicates an impact on balance. However, its influence on the peripheral vestibular receptor has yet to be investigated. Here, we assessed the vestibulotoxicity of styrene using an in vitro model, consisting of three-dimensional cultured newborn rat utricles filled with a high‑potassium (K+) endolymph-like fluid, called "cysts". K+ entry in the cyst ("influx") and its exit ("efflux") are controlled by secretory cells and hair cells, respectively. The vestibular epithelium's functionality is thus linked to K+ concentration, measured using a microelectrode. Known inhibitors of K+ efflux and influx validated the model. Cysts were subsequently exposed to styrene (0.25; 0.5; 0.75 and 1 mM) for 2 h or 72 h. The decrease in K+ concentration measured after both exposure durations was dose-dependent, and significant from 0.75 mM styrene. Vacuoles were visible in the cytoplasm of epithelial cells from 0.5 mM after 2 h and from 0.25 mM after 72 h. The results presented here are the first evidence that styrene may deregulate K+ hom...Continue Reading

References

Jun 1, 1990·Scandinavian Journal of Work, Environment & Health·C MöllerL Bergholtz
Jan 1, 1986·Acta Oto-laryngologica·C DechesneA Sans
Apr 1, 1995·Clinical and Experimental Pharmacology & Physiology·L Vaalavirta, H Tähti
Jan 1, 1994·Critical Reviews in Toxicology·R R MillerA Poole
Jan 1, 1996·International Archives of Occupational and Environmental Health·G CalabreseE De Rosa
Jan 1, 1997·International Archives of Occupational and Environmental Health·E BergamaschiD Mergler
May 30, 1998·Hearing Research·S S Spicer, B A Schulte
Aug 10, 1999·Neurotoxicology and Teratology·P CampoM Roure
Nov 24, 1999·Neurotoxicology and Teratology·G LoquetR Lataye
Feb 27, 2001·Hearing Research·M NicolasJ Barhanin
Feb 28, 2001·Proceedings of the National Academy of Sciences of the United States of America·M C CasimiroK Pfeifer
Mar 29, 2001·Neurotoxicology and Teratology·R LatayeP Bonnet
Jun 26, 2001·Hearing Research·P CampoP Bonnet
Sep 19, 2002·British Journal of Pharmacology·Ambuja S BaleJohn J Woodward
Mar 14, 2003·Neurotoxicology and Teratology·Robert LatayeGeorges Morel
Sep 16, 2003·Nature Neuroscience·Gwénaëlle S G Géléoc, Jeffrey R Holt
Mar 9, 2004·Toxicology·James V RogersJames N McDougal
Jul 21, 2004·Brain Research·Marie-Thérèse NicolasDanielle Demêmes
Jan 15, 2005·Regulatory Toxicology and Pharmacology : RTP·David Calderón-GuzmánHugo Juárez-Olguín
Jan 22, 2005·Archives of Toxicology·François Gagnaire, Cristina Langlais
Feb 9, 2005·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Saumil N MerchantJoseph B Nadol
May 12, 2005·Toxicology and Applied Pharmacology·Ambuja S BaleTimothy J Shafer
May 27, 2005·International Archives of Occupational and Environmental Health·Alexandre VouriotPhilippe P Perrin
Jun 23, 2005·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Sergio MasettoPaolo Valli
Sep 24, 2005·Neurochemical Research·David Calderón-GuzmánBeatriz García-Fernández
Feb 14, 2006·Journal of Occupational and Environmental Medicine·Esko ToppilaPanu Oksa
Sep 23, 2006·Physiology·Hiroshi Hibino, Yoshihisa Kurachi
Apr 11, 2007·Toxicological Sciences : an Official Journal of the Society of Toxicology·Guang-Di ChenDonald Henderson
Jan 1, 2008·International Journal of Occupational Medicine and Environmental Health·Ann-Christin Johnson
Feb 9, 2008·Critical Reviews in Toxicology·Perrine Hoet, Dominique Lison

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Report on Carcinogens : Carcinogen Profiles
National Toxicology Program
IARC Monographs on the Evaluation of Carcinogenic Risks to Humans
Critical Reviews in Toxicology
S J Sumner, T R Fennell
Ceskoslovenská hygiena
Z BARDODEJ
© 2022 Meta ULC. All rights reserved