SU-D-213AB-03: Design Optimization of a HDR Ir-192 Brachytherapy Skin Applicator Using Monte Carlo-Based Dosimetry

Medical Physics
Yun Yang, Mark J Rivard

Abstract

AccuBoost® applicators are designed to deliver boost dose after whole breast irradiation in substitution for electron boost. By augmenting the current design through adding a wedge inside the applicator and atungsten window above the skin surface, the AccuBoost applicators can be used to treat skin cancer. This study aimed to design a skin applicator that could deliver brachytherapy in a conformai and homogeneous manner to the skin while minimizing OAR dose. The 6 cm round AccuBoost applicator served as the foundation for variations of an internal cone, internal wedge, and external window. Monte Carlo (MC) methods (MCNP5)were used for dose characterization and design optimization of these tungsten-alloy components. Specifically, the cone, wedge, and window dimensions were iteratively varied in MC simulations based on HDR Ir-192 dose distributions having (0.5 mm)̂2 voxels in a soft tissue phantom. The design goal was an applicator that can protect tissue > 5 mm while providing lateral dose conformity and a homogeneous dose distribution for tissue < 3 mm. The internal wedge angle governed field size to be irradiated, limiting depth-dose spread into the phantom. Dose conformity was enhanced by the internal cone and collimating win...Continue Reading

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.