SU-D-BRA-05: Prostatectomy Patient's Bladder and Rectum Inter-Fraction Organ Motion and Deformation Can Be Described by a Gaussian Signed Distance Field

Medical Physics
E Hu, S Zhou

Abstract

The inter-fraction organ motion/deformation can be conveniently modeled using Bayesian theory with Normal-gamma conjugate prior if signed distance from any fixed point in space to surface of the organ of interest obeys normal distribution. In this study, we investigated whether the inter-fraction motion/deformation of bladder and rectum observed from clinical prostatectomy patients satisfy this normality condition. 285 treatment planning CT and daily CT-on-rails scans from 7 prostatectomy patients were used in this study. Both bladder and rectum were contoured on all scans. Each patient's daily CT-on-rails scans were registered to his treatment planning CT and the bladder/rectum contours were mapped into treatment planning CT space for analysis. A cubic box with orientations along treatment planning CT image axes is defined to contain all bladders/rectums with 2cm margin. For each voxel inside this box (size: 2mm×2mm×1.5mm), its distance to the bladder/rectum surfaces was measured. Sign is added to the distance to indicate whether a point is inside or outside of an organ of interest. Now the inter-fraction motion/deformation of bladder/rectum can be characterized by the distance variation from the voxels to the bladder/rectum s...Continue Reading

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