SU-E-I-52: Noise Level and Contrast Dependent Behavior of MTF in Iterative Reconstruction CT Imaging

Medical Physics
H Jin, J Kim

Abstract

Iterative reconstruction (IR) technique is growingly used in clinical CT imaging due to its ability to provide improved image quality at lower patient doses. However, the nonlinear frequency response of IR technique, which may affect quantitative analysis, is rarely explored. This study evaluates noise level and contrast dependent behavior of MTF in IR CT imaging with a multi-contrast slit phantom scanned at different dose levels. A multi-contrast slit phantom was created consisting of acrylic panel and aluminum foils of different thickness. Images were acquired on multi-detector CT (Discovery CT750 HD: GE) at two dose levels (10mAs and 200mAs), and were reconstructed using FBP and two IR technique (ASIR50 and VEO). Line spread functions were extracted across slits of two different thickness (80um and 144um) on images scanned at two dose levels, and were Fourier transformed to evaluate the MTFs of IR and FBP reconstruction techniques, producing a total of 12 MTF curves. MTF of 200mAs scan showed clearly higher responses up to 28% than that of 100mAs scan in VEO, marginally higher values up to 5% in ASIR50, and were in good agreement in FBP. At same dose level, the MTFs with higher contrast slit (144um) showed marginally higher ...Continue Reading

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.