SU-E-J-143: Characteristics of Tumor-Motion Surrogate Signals Analyzed Using Empirical Mode Decomposition and Hilbert-Huang Transformation

Medical Physics
S Han-Oh

Abstract

We introduce a novel technique for analyzing tumor-motion surrogate signals using Empirical Mode Decomposition (EMD) and Hilbert-Huang Transformation (HHT). The tumor-motion surrogate signals were acquired (with RPM/Varian), from 20 lung-cancer patients in free-breathing method and its data were decomposed into Intrinsic Mode Functions (IMFs) using EMD. HHT was then applied to each IMF to obtain instantaneous frequency as a function of time. The Result of the frequency information was compared to Fast Fourier Transformation (FFT) and manual calculation of frequency. Correlation of each IMF with the surrogate signal was used to determine the adequate IMF as a faithful tumor-motion surrogate. The surrogate RPM signals were decomposed to 10 ± 1 IMFs on average. The decomposed IMFs showed three categories of frequencies: (1) high frequencies (1 - 10 Hz) such as a noise-like signal, (2) medium frequencies (0.1 - 0.3 Hz), which is potentially a true breathing signal, and (3) low frequencies (0.003 - 0.09 Hz), which behave a baseline drift. The marginal frequency, which is a measure of total amplitude contribution from each frequency, showed an average difference of -0.03 ± 0.07 from the FFT and -0.02 ± 0.05 with the manual calculatio...Continue Reading

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi
Xiaobing LiHaiping Bao
Conference Proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Ranjit A ThuraisinghamHung Nguyen
Conference Proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Lei WangWeili Yan
Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi
Cheng YangPeng Zhou
© 2022 Meta ULC. All rights reserved