SU-E-J-184: Liver Dose Calculation for 90Y Radioembolization with PET/CT

Medical Physics
N Yu, P Xia

Abstract

90Y radioembolization is a promising treatment for unresectable hepatocellular carcinoma. A dose of 120 Gy is typically prescribed to a segment or lobe of the liver, but dose of 90Y in the liver tumor is highly heterogeneous. Recently developed 90Y PET/CT enables the visualization of the injected 90Y distribution with high resolution. The purpose of this study is to develop an integrated system to quantify 3D dose distribution using PET/CT images. According to our institution's protocol, 90Y PET/CT scan is acquired for each patient two hours after radioembolization. Based on the 90Y activity distribution from PET scans, we used a convolution method to calculate radiation dose with a published dose kernel for 90Y. The gross tumor volume (GTV) was retrospectively contoured by a clinician using contrast-enhanced diagnostic CTs. Because of breathing motion and different patient positions between the diagnostic CT and PET/CT, we manually registered these two CT scans by aligning 200 Gy dose line with the center of the intended treatment GTV. The system was integrated with a commercial RT PACS/Review station (MIMVista) through DICOM. The dose obtained was of the resolution of PET scans (2-4 mm). This distribution enables physicians t...Continue Reading

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