SU-E-J-207: Compensation of Target Distortion of Pancreatic Tumor in Free-Breathing CT Using 4D Contour Propagation

Medical Physics
X YangB Yi

Abstract

Due to lack of soft-tissue contrast, target distortion for the upper-abdomen targets such as pancreatic tumors is complicated and requiring sufficient remedy. By applying automatic contour propagation, the authors use the information obtained from 4D CT to test if the deformable image registration compensates the respiration-induced distortion of pancreatic tumor in free breathing (FB) CT images. Ten patients with unresected pancreatic cancer treated with either preoperative or definitive chemoradiation were studied. Pancreas GTVs were delineated on the FB CT. Using deformable image registration, the FB GTV contours were propagated to each phase of the 4D CT images taken right after the FB CT, and were compared with the FB GTV to see difference in tumor volume and tumor size along individual dimensions. A one-dimensional tumor motion in proportion to cos4(ωt) was simulated to calculate the probability distribution function for different magnitude of distortions during FB CT scans, and a binary classification test was conducted to analyze the observed results. The probability distribution function predicted that four out of the ten cases would have substantial target distortion given the variation in target motion amplitudes. Th...Continue Reading

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