SU-E-J-82: Improvement in Reproducibility of Lung Expansion Measures with Respiratory Effort Correction

Medical Physics
K DuJohn E Bayouth

Abstract

Longitudinal measurements of pulmonary function must account for subject variation when assessing radiation-induced changes. Previously, we reported intra-subject reproducibility of Jacobian-based measures of lung tissue expansion using repeat 4DCT scans prior to radiation therapy without correcting for differences in respiratory effort. In this study, we present two normalization schemes that correct ventilation images for variations in respiratory effort. Two repeat 4DCT image acquisitions were collected before treatment from seven patients. Using a tissue volume preserving deformable image registration algorithm, two Jacobian ventilation maps were computed from separate acquisitions. Two effort normalization strategies were investigated using intermediated inspiration phases upon the principles of equivalent tidal volume (ETV) and equivalent lung volume (ELV). Additional experiments were performed to verify the effectiveness of the ETV method. Scatter plots of two ventilation maps and statistical parameters of Jacobian ratio were compared before and after each effort correction approach. The scatter plots of the ventilation maps show improvement in measurement reproducibility using either the ETV or ELV effort correction for...Continue Reading

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