SU-E-l-01: Investigating the Dependence of 2D and 3D Scatter-To-Primary Ratios on Breast Density in Clinical Breast CT

Medical Physics
Jainil P ShahMartin P Tornai

Abstract

To characterize 2D and 3D scatter-to-primary ratios (SPR) and investigate the dependence of SPR on breast density based on clinicalpatient imaging on our dedicated SPECT-CT mammotomography system. As a part of an on-going IRB approved protocol, 7 consented women underwent a breast imaging study with our SPECT-CT system. Using a quasi-monochromatic x-ray cone beam and flat panel detector, 240 projections were obtained. 6 beam stop array (BSA) projections were also obtained over 40 degree intervals. The CT data were scatter corrected using a phantom-validated algorithm based on the BSA technique. For each projection, 2D scatter fluence was determined behind each beam stop shadow through the patient's breast, and cubic spline interpolated throughout the thresholded breast region. 2D SPRs were calculated as the average of 6 measured ratios of scatter projections to scatter corrected (primary) projections. Angular cubic spline interpolation was performed to obtain the remaining 234 azimuthal BSA projections for reconstruction correction. Corrected and uncorrected projection images were individually reconstructed and 3D SPRs calculated as the ratio of difference between primary and un-corrected volumes to primary volumes. Histograms ...Continue Reading

Citations


❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved