SU-E-T-246: Preliminary Normal Tissue Complication Probability (NTCP) Analysis for Radiation Pneumonitis (RP) after Stereotactic Body Radiotherapy (SBRT)

Medical Physics
Jimm GrimmSuresh Senan

Abstract

NTCP analysis was performed with Lyman model to study the dose tolerance limits for radiation-induced pneumonitis (RP) in hypofractionated SBRT. Since SBRT is increasingly being applied for the treatment of large and central tumors, it is important from a clinical point of view to determine the dose tolerance limits for specific risk of toxicity. Eighteen consecutive patients who were treated using volumetric modulated arc therapy (RapidArc) for lung tumors exceeding 80cc were assessed. The evaluation of toxicity was scored using Common Toxicity Criteria AE4.0. Median follow-up time was 12.8 months. Clinical outcomes have been published, and we performed an NTCP analysis to determine the complication rate in relation to statistical dose tolerance limits. The dose volume histogram (DVH) reduction techniques of the total lung V20Gy, V15Gy, V10Gy, V5Gy and mean lung dose (MLD) were each analyzed, as well as the ipsilateral lung V5Gy and the contralateral lung V5Gy. The framework of the Lyman Model was used except that each DVH reduction method was analyzed independently instead of using the power-law relationship for volume dependence. Model parameters were fitted using the Maximum Likelihood technique. RP was reported in 5 patien...Continue Reading

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