SU-E-T-251: Analysis of Irradiated Induced Lung Injury in Non-Small Cell Lung Cancer (NSCLC) Treated by Three-Dimensional Conformal Radiotherapy(3DCRT)

Medical Physics
Z LiuS Zhu

Abstract

The aim of this study was to analyze the affect factors with radiation induced lung injury of NSCLC treated by 3DCRT, in order to supply reference criteria for optimize the treatment planning, further to improve the local control rate and the quality of life of NSCLC patients. From August 2000 to December 2004, 107 NSCLC patients received 3DCRT were retrospectively enrolled in this study. All of patients received the prescription doses ranged from 60-68Gy with a median dose of 66Gy. Dosimetric parameters of dose-volume histograms from 3DCRT plans was recorded. The lung injury were assessed for each patient during the treatment and follow-up within 3 months after treatment completion. Acute radiation induced pneumonitis were graded by one radiation oncologist according to the RTOG/EORTC criteria. The correlation between dosimetric parameters with lung injury was evaluated by univariate and multivariate analysis using Logistic Regression Model of SPSS11.0 software. In the 107 patients of NSCLC, the rate of irradiated induced lung injury was 62.6% and the rate of =2 grade radiation induced pneumonitis was 38.3%. Twenty-three cases were classified in grade 2, fourteen cases in grade 3, four cases in grade 4. Univariate analysis sho...Continue Reading

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