SU-E-T-254: Quantitative Evaluation of Three Mathematical Models for Radiation-Induced Secondary Cancer Risk for Lung in Stereotactic Body Radiotherapy

Medical Physics
Chunhui HanJ Wong

Abstract

Several mathematical models exist to predict secondary cancer risks from radiotherapy treatment. In this study, we aimed to compare three dosimetry-based models in the application of stereotactic body radiotherapy (SBRT) of early-stage non-small cell lung cancer (NSCLC) with three radiotherapy treatment modalities. Ten patients who received definitive SBRT for early-stage NSCLC were retrospectively selected. for each patient, a helical tomotherapy (HT) plan, a three-dimensional conformal radiotherapy (3D-CRT) plan, and a volumetric modulated arc therapy (VMAT) plan were generated to deliver 50 Gy to the planning target volume in five fractions. The excess absolute risk (EAR) for secondary lung cancer occurrence was calculated using three risk models: the linear-exponential model, the plateau model, and the linear model. The sensitivity of the EAR to the prescription dose was evaluated by varying the prescription dose in the range of 40 to 60 Gy. Based on the linear-exponential model, the average EAR's (in occurrences per 10,000 patients per year) were 8.4+/-2.7, 8.3+/-2.1, and 8.4+/-1.9 for the HT plans, 3D-CRT plans, and VMAT plans respectively with 40 Gy prescription dose, and 9.4+/-2.5, 9.0+/-2.1, and 9.3+/-1.8 with 60 Gy. B...Continue Reading

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