SU-E-T-293: The Potential Application of High Energy Proton Beam-Induced Positron for PET Imaging Technique

Medical Physics
E Kumi BarimahC Keppel

Abstract

An existing nuclear interaction cross-section of a positron emitter was used to predict range accuracy of proton beams and cross section of the positron emitters detected by the PET scanner Methods: To achieve this goal, a MLIC phantom was irradiated to 2Gy dose using 124.61MeV, 143.08MeV and 155.25MeV proton beam corresponding to the depths of 6.88cm, 10cm and 16cm, respectively, in the phantom. The activity produced in each phantom was examined by PET scanner within a couple of minutes post-irradiation. Hence, activity signal produced along the activated depth dose profile was recorded. In this project, the isotope production cross section for carbon from Landolt-Bornstein (1973) has been utilized. A good correlation (about 95%) between the positron emission and the isotope cross section of the carbon was observed. Consistency between the induced activity and the carbon isotope cross section occurred mainly at the distal aspect of the fall off zone of both relative cross-sections (i.e. between 60 - 100%). These results were obtained using the high relative abundance of carbon (i.e. 70%) in the phantoms.Conclusions The ranges measured by the depth dose profiles and positron emission profiles were in good agreement at the dista...Continue Reading

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.