SU-E-T-294: Maximizing the Availability of Positron Emitting Nuclei for Proton Therapy Verification Using Different Beam Irradiation Sequences

Medical Physics
M YagiT Teshima

Abstract

To demonstrate that the amount of nuclei available for post- irradiation proton treatment verification using positron emission tomography (PET) can be enhanced by reversing the beam delivery sequence in proton scanning beam irradiations. A time-dependent analytical model is used to calculate the distributions of positron emitting nuclei for three different irradiation sequences: a scattered beam and a scanning beam in both the conventional sequence, distal edge first, and reverse sequence, distal edge last. The simulated geometry emulates reference dosimetry measurements conducted at the Paul Scherrer Institute (PSI). The reference measurements irradiate a 10 ×10 cm(2) field, delivering about 1 Gy to a 10 cm wide spread-out Bragg peak (SOBP). Positron emitter availability with different beam sequence and imaging times and the impact of the different irradiation sequences on the statistical error on a range extrapolation were investigated. The ratio of the amount of positron emitters from the distal last beam sequence to that from the distal first sequence was 2.22 in the last centimeter of the SOBP. The comparison between distal last and a scattered beam gave a ratio of about 1.7 in the same region. In the distal last irradiati...Continue Reading

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