SU-E-T-303: Practical Considerations for Maximizing Heat Production in Novel Thermo-Brachytherapy Seed Prototype

Medical Physics
Bhoj GautamE Ishmael Parsai

Abstract

Our recently proposed thermo-brachytherapy seed offers a convenient approach to radiation sensitization with heat in treatment of solid tumors through concurrent administration of hyperthermia and brachytherapy. The seed consists of a titanium capsule, containing radioactive I-125 and a ferromagnetic core, serving as a source of self-regulating hyperthermia when placed in an alternating electromagnetic field. We present an experimental study of the magnetic properties of ferromagnetic Ni-Cu alloy, and develop a protocol for obtaining the material capable of the maximum heat generation. Based on the practically achievable temperature interval we evaluate the effect of thermal expansion on the seed components during the hyperthermia treatment. Alloy samples of Ni1-xCux (0.28= × =0.3) were prepared by arc melting method in argon atmosphere. The ingots were annealed in vacuum at 1000°C for 12 hours. These samples were cut into pieces and used for magnetization measurements with SQUID magnetometer. The thermal expansion along greatest dimension of each component of the purposed seed was estimatedfor temperature increase from 37 to 60 ËšC. The annealed samples show sharp Curie transition at temperature TC∼50°C, varying with the alloy...Continue Reading

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