SU-E-T-319: Monte Carlo Characterization of a New Directional Pd-103 High Dose Rate Source for Brachytherapy Application

Medical Physics
A HerediaB Thomadsen

Abstract

Standard brachytherapy sources emit radiation in a non-preferential direction away from the source. Though treatment outcomes are good, this can lead to late skin and subcutaneous toxicities in sensitive structures. Proposed low dose rate directional sources for interstitial brachytherapy, showed to have an improvement in the dose uniformity within the subcutaneous volume, reduction in skin dose, and reduction in volume receiving dose outside the target. The objective of this work is to demonstrate the potential use of a new Pd-103 directional seed for application in high dose rate brachytherapy treatments. Monte Carlo simulations were performed using the MCNP5 F6 energy deposition tallies as well as the MCNP5 F4 flux density tallies placed around a partially shielded Pd-103 source at angles(deg): 0, 45, 90, 135, 180, 225, 270, 315 as well as radial distances (cm): 0.5, 1, 1.5, 2, 3, 4, 5, 6, 7, 8, 9, 10. The source that modeled was a Pd-103 core using TG-43U recommended nuclear data, with a diameter = 1.4 mm, active length = 1.0 cm. In addition osmium metal with .03 mm thickness was used as shielding material to cover half of the cylindrical surface of the Pd-103 volume. The seed was encapsulated using .05 mm thick titanium. M...Continue Reading

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)
Pooneh SaidiClaudio Tenreiro
Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine
Hamid Saeed RazaSung Oh Cho
© 2022 Meta ULC. All rights reserved