SU-E-T-408: Enhancing Stereotactic Radiosurgery for Neovascular Age-Related Macular Degeneration, Using Gold Nanoparticles

Medical Physics
W NgwaRoss I Berbeco

Abstract

Age-related macular degeneration (AMD) is the leading cause of irreversible vision loss for people over the age of 60 in the United States. In this study the dosimetric feasibility of using gold nanoparticles (AuNP) as radiosensitizers to enhance stereotactic radiosurgery for neovascular AMD is investigated. Analytic calculations were carried out to estimate the nucleus dose enhancement factor (nDEF) due to photon-induced photo- /Auger electrons from AuNP targeting neovascular AMD endothelial cells (EC). The nDEF represents the ratio of the dose to the nucleus with and without the presence of AuNP. As in previous studies, the EC is modeled as a slab of 2 μm (thickness) × 10 μm (length) × 10 μm (width) containing a nucleus of 5 μm diameter and thickness of 0.5 - 1 μm. The targeted AuNP are attached to the exterior of the EC. The nDEF was calculated for a range of feasible AuNP local concentrations (1-7 mg/g) using the clinically applicable 100 kVp x-rays employed by the IRayTM system (Oraya Therapeutics Inc. Newark, CA), with total filtration of 0.75 mm Al and 0.8 mm Be. For comparison the nDEF for other energies: 80 kVp, 90 kVp, 110 kVp, and 120 kVp was also investigated. For 100 kVp x-rays, the results revealed nDEF values of ...Continue Reading

Citations

May 17, 2018·Medicinal Research Reviews·Florence MasseElodie Boisselier
Aug 28, 2021·Nanomaterials·Rahul SharmaNikhlesh K Singh

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.