SU-E-T-463: Biological-Based Optimization and VMAT is Unnecessary for Stereotactic Body Radiation Therapy

Medical Physics
D MihailidisG Kagadis

Abstract

This study shows that there is no clear dosimetric benefit of biological-based optimization for either fixed-beam IMRT or VMAT. Other than shorter delivery times, even VMAT does not offer additional advantage to fixed-beam IMRT. A small number of patients for lung, pancreas, spine and brain CA were planned with fixed-beam IMRT, optimized with (gEUD) and without (DV) biological objectives and, also planned for VMAT with and without gEUD, for comparison. For the lung and brain cases, a non-coplanar 7-11 beam arrangement was used for fixed- beam IMRT and a coplanar 'hybrid' arc simulated VMAT with beams set every 5° spacing. For the other treatment sites, all beams were coplanar. For each case, the fixed-beam IMRT and VMAT plans were optimized with the same objectives. It is important to note that, only 2 segments/beam were allowed for each plan, in order to create small fluence modulation, appropriate for small target volumes during SBRT. For all plans we noticed that there were minor or no dosimetric differences between fixed- beam IMRT and VMAT, whether DV or gEUD objectives were used or whether fixed-beam IMRT or VMAT is used. Keeping the level of beam modulation as-low-as possible, for small SBRT targets, one can show that VM...Continue Reading

Citations


❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.