SU-E-T-500: Pencil-Beam versus Monte Carlo Based Dose Calculation for Proton Therapy Patients with Complex Geometries. Clinical Use of the TOPAS Monte Carlo System

Medical Physics
J SchuemannH Paganetti

Abstract

To investigate the necessity of the verification of dose distributions using Monte Carlo (MC) simulations for proton therapy of head and neck patients and other complex patient geometries. TOPAS, a TOol for PArticle Simulations that makes MC simulations easy-to-use for research and clinical use and is layered on top of Geant4, has been used to simulate the treatments of head and neck patients at the Massachusetts General Hospital (MGH). The resulting dose distributions have been compared to pencil beam calculations based on the XiO treatment planning system. Dose difference distributions were used to highlight areas where the two algorithms did not agree. Dose volume histograms are utilized to investigate the overall agreement of the planned doses in target structures. 21 head and neck patients, both nasopharynx and spinal cord, were investigated. The field complexity ranges from a single field up to 13 fields. For all patients, the dose in the clinical target volume agrees well. Nevertheless, differences in critical structures around the targets have been observed mostly due to range differences between the two algorithms. Pencil beam algorithms provide an accurate description of dose in the target volume. However, we conclude...Continue Reading

Citations

Nov 28, 2019·International Journal of Particle Therapy·Balu Krishna SasidharanStephen R Bowen

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