SU-E-T-582: Assessment of Improved Critical Structure Sparing Using Biologically- Based Optimization for Volumetric Modulated Arc Therapy of Head and Neck Cancer

Medical Physics
Nesrin Dogan, Y Wu

Abstract

To investigate the critical structure sparing achievable by biological optimization for modulated volumetric arc (VMAT) of head and neck (H&N) cancer. Ten H&N VMAT patients who were originally planned and treated with simultaneous integrated boost technique using dose-volume based optimization, were selected. For each patient, a new VMAT plan was generated using the generalized equivalent uniform dose (gEUD)-based biological optimization available in Pinnacle3 Smart Arc. While the objectives for targets were defined in terms of minimum and maximum EUDs with 'a' values of -15 and +15, the critical structure objectives were defined in terms of maximum EUDs with 'a' values of'1', '5' and '10'. Both dose-volume and gEUD-based VMAT plans used 6MV, 280 degree dual arcs. The prescription doses for all cases were 70Gy to PTV1, 60Gy to PTV2 and 54Gy to PTV3 delivered in 33 fractions. The critical structures included cord, parotids, brainstem, and esophagus. The critical structure sparing in physical and biological plans were assessed using dose- volume indices, including D2, D50, and Dmean, and MUs and treatment delivery times. PTV coverage obtained by both dose-volume and biological-based optimization were generally very similar, altho...Continue Reading

Citations

Nov 21, 2017·Journal of Applied Clinical Medical Physics·Antonella FogliataLuca Cozzi
Oct 11, 2019·Veterinary Radiology & Ultrasound : the Official Journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association·Valeria MeierCarla Rohrer Bley

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