SU-E-T-607: Determining Critical Objectives and Importance Factors for Prostate IMRT Treatment Planning

Medical Physics
T LeeMichael B Sharpe

Abstract

To determine the optimization objectives that are most critical in prostate IMRT treatment planning, and to demonstrate that clinically acceptable treatments can be obtained using fewer optimization objectives with intelligently chosen importance factors. We develop a novel optimization method that uses a historical prostate IMRT treatment as an input to quantify importance factors for a given set of objectives in the treatment planning problem. An initial treatment planning formulation with many candidate objectives is formulated. Then, given a historical treatment, importance factors for the objectives are determined via inverse optimization. We analyzed the results over several patients and identified the most critical optimization objectives in prostate IMRT treatment planning. We then designed a new treatment planning formulation with only the critical objectives, determined the importance factors via inverse optimization, and then compared the dose distribution to that of the original planning problem. The method was applied to a homogeneous cohort of 12 patients from Princess Margaret Hospital. A treatment plan generated using 18 objectives was replicated using only six objectives and inversely-optimized importance facto...Continue Reading

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