Suanzaoren Formulae for Insomnia: Updated Clinical Evidence and Possible Mechanisms

Frontiers in Pharmacology
Qi-Hui ZhouYan Lin

Abstract

Insomnia disorder is a widespread and refractory disease. Semen Ziziphi Spinosae, Suanzaoren, a well-known Chinese herbal medicine, has been used for treating insomnia for thousands of years. Here, we aimed to assess the available evidence of Chinese herbal formulae that contains Suanzaoren (FSZR) for insomnia according to high-quality randomized controlled trials (RCTs) and reviewed their possible mechanisms based on animal-based studies. Electronic searches were performed in eight databases from inception to November 2016. The primary outcome measures were polysomnography index and Pittsburgh sleep quality index. The secondary outcome measures were clinical effective rate and adverse events. The methodological quality of RCTs was assessed by Cochrane's collaboration tool, and only RCTs with positive for 4 out of 7 for the Cochrane risk of bias domains were included in analyses. Thirteen eligible studies with 1,454 patients were identified. Meta-analysis of high-quality RCTs showed that FSZR monotherapy was superior to placebo (P < 0.01); FSZR plus Diazepam was superior to Diazepam alone (P < 0.05); there were mixed results comparing FSZR with Diazepam (P > 0.05 or P < 0.05). Furthermore, FSZR caused fewer side effects than th...Continue Reading

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Citations

Apr 11, 2020·International Journal of Nanomedicine·Chang-Shun LiuXiao-Mei Tan
Sep 12, 2019·Frontiers in Pharmacology·Jian GaoZhiwei Cao
Jul 4, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Liang-Hui ZhanSu-Hong Chen
Feb 25, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Ming-Fen SongYong-Hua Zhang
Jan 2, 2021·Complementary Therapies in Medicine·Johannah L ShergisMelinda L Jackson

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Methods Mentioned

BETA
profiler

Software Mentioned

Cochrane Collaboration Review Manager
RevMan
GRADE

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