Sub-50-fs laser retinal damage thresholds in primate eyes with group velocity dispersion, self-focusing and low-density plasmas

Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie
Clarence P CainBenjamin A Rockwell

Abstract

In vivo retinal injury studies using sub-50-femtosecond laser pulses in the near-infrared must consider nonlinear effects such as group velocity dispersion (GVD), self-focusing, laser-induced breakdown (LIB) and low-density plasmas (LDPs). In this paper we present the results of our theoretical calculations of nonlinear effects and our experimental measurements for the visible lesion thresholds in live eyes. We compare these values with the measured LIB and LDP thresholds in an artificial eye. All three thresholds were measured with and without pre-chirping the input pulse to compensate for GVD effects. We recorded the minimum visible lesion (MVL) thresholds in vivo for sub-50-fs laser pulses, with and without pre-chirping the input pulses. In addition, we measured the LIB and LDP thresholds, with and without pre-chirping, within an artificial eye. Different degrees of pre-chirping were required to give optimal compensation for GVD in the live eye and the artificial eye. Probit analysis was used on all data, and comparisons among thresholds were made, to determine the effects on the three thresholds of chirp compensation for GVD. Results of our nonlinear modeling and calculations for GVD compensation, self-focusing, LIB, and lo...Continue Reading

References

Nov 1, 1983·Journal of the Optical Society of America·A C Kooijman
Aug 1, 1996·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·C P CainW P Roach
Sep 4, 1999·Journal of the Optical Society of America. A, Optics, Image Science, and Vision·D X HammerB A Rockwell
Feb 28, 2002·Physical Review Letters·Vasan VenugopalanAlfred Vogel
Jun 15, 1994·Optics Letters·G G LutherE M Wright
Jan 1, 1997·Journal of Biomedical Optics·C P CainB A Rockwell

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Citations

Sep 22, 2007·Lasers in Surgery and Medicine·Hui SunJosef F Bille
Jun 15, 2005·Lasers in Surgery and Medicine·Semih S KumruBenjamin A Rockwell
Aug 25, 2020·Translational Vision Science & Technology·Kamal R DhakalWilliam H Merigan
Apr 10, 2008·Current Eye Research·Matthias HildKarsten König
Dec 27, 2016·Biomedical Optics Express·Christina SchwarzJennifer J Hunter
Sep 1, 2013·Health Physics·UNKNOWN International Commission on Non-Ionizing Radiation Protection

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