Sub-acute nickel exposure impairs behavior, alters neuronal microarchitecture, and induces oxidative stress in rats' brain

Drug and Chemical Toxicology
Omamuyovwi M IjomoneAzubike Peter Ebokaiwe

Abstract

Nickel (Ni) is a heavy metal with wide industrial uses. Environmental and occupational exposures to Ni are potential risk factors for neurological symptoms in humans. The present study investigated the behavior and histomorphological alterations in brain of rats sub-acutely exposed to nickel chloride (NiCl2) and the possible involvement of oxidative stress. Rats were administered with 5, 10 or 20 mg/kg NiCl2 via intraperitoneal injections for 21 days. Neurobehavioral assessment was performed using the Y-maze and open field test (OFT). Histomorphological analyses of brain tissues, as well as biochemical determination of oxidative stress levels were performed. Results showed that Ni treatments significantly reduced body weight and food intake. Cognitive and motor behaviors on the Y-maze and OFT, respectively, were compromised following Ni treatments. Administration of Ni affected neuronal morphology in the brain and significantly reduced percentage of intact neurons in both hippocampus and striatum. Additionally, markers of oxidative stress levels and nitric oxide (NO) levels were significantly altered following Ni treatments. These data suggest that compromised behavior and brain histomorphology following Ni exposures is associa...Continue Reading

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Citations

May 22, 2020·Annals of Clinical and Translational Neurology·Claudia Figueroa-RomeroChristine Austin
Jul 19, 2019·Oxidative Medicine and Cellular Longevity·Ken-Ichiro TanakaMasahiro Kawahara
Jun 20, 2020·Environmental Science and Pollution Research International·Isela Hernández-PlataPatricia Mussali-Galante
Aug 23, 2020·International Journal of Environmental Research and Public Health·Bianca GerardoSandra Freitas
Nov 20, 2020·Critical Reviews in Toxicology·Omamuyovwi M IjomoneMichael Aschner
Dec 4, 2019·Endocrine, Metabolic & Immune Disorders Drug Targets·María I Martínez-MartínezOmar Cauli
Nov 30, 2019·Endocrine, Metabolic & Immune Disorders Drug Targets·Thea MagroneEmilio Jirillo
Jan 13, 2021·Environmental Analysis, Health and Toxicology·Mouloud LamtaiAli Ouichou
Feb 12, 2021·Metallomics : Integrated Biometal Science·Ruedeemars YubolphanPornpun Vivithanaporn
Nov 17, 2020·EFSA Journal·UNKNOWN EFSA Panel on Contaminants in the Food Chain (CONTAM)Elsa Nielsen
Sep 4, 2020·Neurotoxicology·Omamuyovwi M IjomoneMichael Aschner
May 21, 2021·Drug and Chemical Toxicology·Omamuyovwi M IjomoneAzubuike P Ebokaiwe

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