Sub-classification of Advanced-Stage Hepatocellular Carcinoma: A Cohort Study Including 612 Patients Treated with Sorafenib

Cancer Research and Treatment : Official Journal of Korean Cancer Association
Jeong-Ju YooSeoul Liver Group

Abstract

Advanced hepatocellular carcinoma (HCC) is associated with various clinical conditions including major vessel invasion, metastasis, and poor performance status. The aim of this study was to establish a prognostic scoring system and to propose a sub-classification of the Barcelona-Clinic Liver Cancer (BCLC) stage C. This retrospective study included consecutive patientswho received sorafenib for BCLC stage C HCC at a single tertiary hospital in Korea. A Cox proportional hazard model was used to develop a scoring system, and internal validationwas performed by a 5-fold cross-validation. The performance of the model in predicting risk was assessed by the area under the curve and the Hosmer-Lemeshow test. A total of 612 BCLC stage C HCC patients were sub- classified into strata depending on their performance status. Five independent prognostic factors (Child-Pugh score, α-fetoprotein, tumor type, extrahepatic metastasis, and portal vein invasion) were identified and used in the prognostic scoring system. This scoring system showed good discrimination (area under the receiver operating characteristic curve, 0.734 to 0.818) and calibration functions (both p < 0.05 by the Hosmer-Lemeshow test at 1 month and 12 months, respectively). T...Continue Reading

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Citations

Nov 8, 2018·Journal of Korean Medical Science·Bo Hyun Kim, Joong-Won Park
Oct 4, 2019·Liver International : Official Journal of the International Association for the Study of the Liver·Tim A LabeurPhilip J Johnson
Jun 3, 2021·Cancers·Giovanni MarascoOn Behalf Of The Italian Liver Cancer Ita Li Ca Group

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Methods Mentioned

BETA
surgical resection
CLIP

Software Mentioned

R

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