Sub-Classification of Cirrhosis Affects Surgical Outcomes for Early Hepatocellular Carcinoma Independent of Portal Hypertension.

Frontiers in Oncology
Er-Lei ZhangZhi-Yong Huang

Abstract

Severity of liver cirrhosis is distinct from clinical portal hypertension because there exist different degrees of liver cirrhosis in hepatocellular carcinoma (HCC) patients without significant clinical portal hypertension. Whether severity of cirrhosis affects surgical outcomes for HCC patients in absence of portal hypertension or not remains unclear. This study aims to analyze the effect of cirrhotic severity on surgical outcomes for HCC patients with hepatitis B virus (HBV) infection in absence of portal hypertension. This retrospective study enrolled 166 patients who underwent curative resection for a single HCC ≤5 cm in absence of portal hypertension between February 2011 and December 2013. Liver cirrhosis was sub-classified into no/mild (no/F4A) and moderate/severe (F4B/F4C) according to the Laennec scoring system. The surgical outcomes and complications were analyzed. The surgical mortality was zero in this study. Major complications were apparently higher in the F4B/F4C group than in the no/F4A group (17.0% vs 7.4%, p <0.001). The 1-year, 3-year and 5-year overall survival (OS) rates were 98.5, 88.1 and 80%, respectively, in the no/F4A group, which were significantly higher than those in the F4B/F4C group (98.0, 69.2 an...Continue Reading

References

Jul 26, 2005·Annals of Surgery·Kiyoshi HasegawaMasatoshi Makuuchi
Jun 6, 2009·World Journal of Gastroenterology : WJG·Ken ShirabeYoshihiko Maehara
Jan 16, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Guadalupe Garcia-TsaoMassimo Pinzani
Mar 6, 2010·World Journal of Gastroenterology : WJG·Peng LiuYan-Ming Zhou
Feb 15, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Kyu Sik JungKwang-Hyub Han
Jan 20, 2012·Annals of Surgery·Brian ShragerSasan Roayaie
Aug 7, 2012·Lancet·Roberto S OliveriChristian Gluud
Sep 5, 2012·ANZ Journal of Surgery·Savio G BarretoJohn W C Chen
Feb 4, 2014·Liver International : Official Journal of the International Association for the Study of the Liver·Seung Up KimYoung Nyun Park
Nov 26, 2014·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Zhangjun ChengFeng Shen
Feb 14, 2015·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Sasan RoayaieMorris Sherman
Jul 28, 2015·Liver International : Official Journal of the International Association for the Study of the Liver·Gaeun KimMee Yon Cho
Jan 30, 2016·Clinics and Research in Hepatology and Gastroenterology·Qian ZhuYi-Qun Yan
Mar 21, 2016·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·E-L ZhangZ-Y Huang
Aug 28, 2016·The Journal of Surgical Research·Er-Lei ZhangZhi-Yong Huang
Feb 9, 2018·Science China. Life Sciences·Binhao ZhangXiaoping Chen
Aug 8, 2018·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Jianwei LiuFeng Shen
Aug 18, 2018·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Han WangWen-Ming Cong
Feb 23, 2019·Annals of Surgical Oncology·Derek J Erstad, Kenneth K Tanabe

❮ Previous
Next ❯

Software Mentioned

SPSS
SPSS19

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.