Sub-inhibitory concentrations of heavy metals facilitate the horizontal transfer of plasmid-mediated antibiotic resistance genes in water environment

Environmental Pollution
Ye ZhangJianmin Chen

Abstract

Although widespread antibiotic resistance has been mostly attributed to the selective pressure generated by overuse and misuse of antibiotics, recent growing evidence suggests that chemicals other than antibiotics, such as certain metals, can also select and stimulate antibiotic resistance via both co-resistance and cross-resistance mechanisms. For instance, tetL, merE, and oprD genes are resistant to both antibiotics and metals. However, the potential de novo resistance induced by heavy metals at environmentally-relevant low concentrations (much below theminimum inhibitory concentrations [MICs], also referred as sub-inhibitory) has hardly been explored. This study investigated and revealed that heavy metals, namely Cu(II), Ag(I), Cr(VI), and Zn(II), at environmentally-relevant and sub-inhibitory concentrations, promoted conjugative transfer of antibiotic resistance genes (ARGs) between E. coli strains. The mechanisms of this phenomenon were further explored, which involved intracellular reactive oxygen species (ROS) formation, SOS response, increased cell membrane permeability, and altered expression of conjugation-relevant genes. These findings suggest that sub-inhibitory levels of heavy metals that widely present in various ...Continue Reading

References

Jul 28, 1999·Applied Microbiology and Biotechnology·D H Nies
Apr 27, 2000·Journal of Bacteriology·A L SamuelsJ E Davies
May 10, 2000·The Journal of Nutrition·S R Powell
Feb 24, 2001·Journal of Bacteriology·M ZatykaC M Thomas
Nov 8, 2001·Biological Trace Element Research·R K Anand, U Kanwar
Dec 4, 2004·Nature Medicine·Stuart B Levy, Bonnie Marshall
Mar 16, 2006·Trends in Microbiology·Craig Baker-AustinJ V McArthur
May 5, 2006·Applied and Environmental Microbiology·Robert J MartinezPatricia A Sobecky
Aug 18, 2006·Environmental Microbiology·Ramunas StepanauskasJ V McArthur
Dec 23, 2008·Biochimica Et Biophysica Acta·Anne H Delcour
Oct 24, 2009·Journal of Occupational Health·Keiko AsakuraKazuyuki Omae
Mar 2, 2010·Nature Reviews. Microbiology·Heather K AllenJo Handelsman
Nov 18, 2011·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Mélanie MermodJivko V Stoyanov
Mar 14, 2012·Proceedings of the National Academy of Sciences of the United States of America·Zhigang QiuJun-Wen Li
Aug 15, 2012·FEMS Microbiology Letters·Satoru SuzukiHabibur M Rahman
Feb 13, 2013·Proceedings of the National Academy of Sciences of the United States of America·Yong-Guan ZhuJames M Tiedje
May 15, 2013·Nature Reviews. Microbiology·Joseph A LemireRaymond J Turner
Jul 11, 2013·Environmental Health Perspectives·Nicholas J AshboltEdward Topp
Dec 12, 2013·BMC Pharmacology & Toxicology·Jérôme BretonBenoît Foligné
May 28, 2014·Nature Reviews. Microbiology·Dan I Andersson, Diarmaid Hughes
May 31, 2014·Environment International·Yanguo TengLiuting Song
Dec 3, 2014·Environmental Pollution·J A Rodríguez MartínR Boluda
Dec 24, 2014·Nature Reviews. Microbiology·José L MartínezFernando Baquero
Mar 31, 2015·Nature Reviews. Microbiology·Thomas U BerendonkJosé Luis Martinez

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Citations

Jan 18, 2020·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·May Linn BubergYngvild Wasteson
Aug 1, 2020·International Journal of Environmental Health Research·João Pedro Rueda FurlanEliana Guedes Stehling
Jun 30, 2019·International Journal of Environmental Research and Public Health·Wen ShaoKeyao Zhang
Oct 28, 2019·Antimicrobial Resistance and Infection Control·Guyue ChengZonghui Yuan
Aug 6, 2020·Environmental Science and Pollution Research International·Ivana TimkováJana Sedláková-Kaduková
Sep 29, 2020·Frontiers in Microbiology·Sara Hernando-AmadoJosé L Martínez
Jan 17, 2020·International Journal of Environmental Research and Public Health·Alexandra BastaraudRonan Jambou
Mar 5, 2020·The Journal of Antimicrobial Chemotherapy·Zhenpeng LiFang Bai
Jan 9, 2021·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Abdelaziz TouatiAssia Mairi
Dec 21, 2020·The Science of the Total Environment·Xiang XiaoHan-Qing Yu
Oct 30, 2020·Environment International·Ioannis D KampourisThomas U Berendonk
Feb 5, 2021·Environmental Pollution·Majid KomijaniMohammad Bahram
Oct 31, 2020·Environmental Geochemistry and Health·Zibo LinQiyan Feng
Feb 12, 2021·The Science of the Total Environment·Hai-Yan ZouGuang-Guo Ying
Nov 7, 2020·Environmental Science and Pollution Research International·Polina GalitskayaSvetlana Selivanovskaya
Feb 26, 2021·Environmental Pollution·Marion HutinelCarl-Fredrik Flach
Apr 16, 2021·Frontiers in Microbiology·Magdalena ZalewskaMagdalena Popowska

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