Sub-microscopic infections and long-term recrudescence of Plasmodium falciparum in Mozambican pregnant women.

Malaria Journal
Alfredo MayorC Menendez

Abstract

Control of malaria in pregnancy remains a public health challenge. Improvements in its correct diagnosis and the adequacy of protocols to evaluate anti-malarial drug efficacy in pregnancy, are essential to achieve this goal. The presence of Plasmodium falciparum was assessed by real-time (RT) PCR in 284 blood samples from pregnant women with clinical complaints suggestive of malaria, attending the maternity clinic of a Mozambican rural hospital. Parasite recrudescences in 33 consecutive paired episodes during the same pregnancy were identified by msp1 and msp2 genotyping. Prevalence of parasitaemia by microscopy was 5.3% (15/284) and 23.2% (66/284) by RT-PCR. Sensitivity of microscopy, compared to RT-PCR detection, was 22.7%. Risk of maternal anaemia was higher in PCR-positive women than in PCR-negative women (odds ratio [OR] = 1.92, 95% confidence interval [CI] 1.09-3.36). Genotyping confirmed that recrudescence after malaria treatment occurred in 7 (21%) out of 33 pregnant women with consecutive episodes during the same pregnancy (time range between recrudescent episodes: 14 to 187 days). More accurate and sensitive diagnostic indicators of malaria infection in pregnancy are needed to improve malaria control. Longer follow-up...Continue Reading

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Citations

Mar 27, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Alfredo MayorClara Menéndez
Nov 3, 2010·Infection and Immunity·Elisa Serra-CasasAlfredo Mayor
Jul 9, 2011·Malaria Journal·Krijn P Paaijmans, Matthew B Thomas
Apr 13, 2012·Malaria Journal·Beatriz C JiménezLaura Molina
Apr 17, 2012·Malaria Journal·Machteld E BoelRose McGready
Aug 10, 2010·Malaria Journal·Judith H Waknine-GrinbergJacob Golenser
Feb 6, 2010·The American Journal of Tropical Medicine and Hygiene·Marielle K Bouyou-AkotetMaryvonne Kombila
Jul 8, 2011·The American Journal of Tropical Medicine and Hygiene·W M Kumudunayana T de A W GunasekeraS Deepika Fernando
Jan 11, 2012·The American Journal of Tropical Medicine and Hygiene·Mehul DhordaGeorges Snounou
Dec 15, 2010·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Clara MenéndezAlfredo Mayor
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Mar 21, 2013·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Hamza A BabikerLisa C Ranford-Cartwright
Dec 29, 2015·Trends in Parasitology·Beatriz GalatasAlfredo Mayor
Dec 17, 2010·BJOG : an International Journal of Obstetrics and Gynaecology·R McGreadyF Nosten
Mar 17, 2016·Malaria Journal·Mercedes RubioAlfredo Mayor
Jan 7, 2014·British Journal of Haematology·Ruth AguilarClara Menéndez
Sep 19, 2015·Malaria Journal·María Fernández LópezNoemi Cabello Clotet
Oct 22, 2015·The New England Journal of Medicine·Alfredo MayorClara Menéndez
Oct 11, 2017·The American Journal of Tropical Medicine and Hygiene·Esto BahizirePhilippe Donnen
Dec 21, 2017·Emerging Infectious Diseases·Himanshu GuptaAlfredo Mayor
Apr 18, 2014·Journal of Clinical Microbiology·Steve M TaylorSteven R Meshnick
Nov 1, 2018·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Carlota DobañoPedro L Alonso
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Jan 30, 2015·Pathogens and Global Health·Neeru SinghBlair J Wylie
Apr 24, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Aaron M SamuelsMeghna R Desai

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Methods Mentioned

BETA
PCR
genotyping

Software Mentioned

Visual FoxPro
STATA
ABI Prism SDS2

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