Sub-parts per billion detection of trace volatile chemicals in human breath using selected ion flow tube mass spectrometry.

BMC Research Notes
Brian M Ross

Abstract

Selected ion flow tube mass spectrometry (SIFT-MS) allows the real time quantification of trace gases in air. Due to its tolerance of high humidity levels the technique is particularly suited to the chemical analysis of breath. The detection limit of SIFT-MS has previously reported to be approximately 5 - 10 PPBV which is insufficient for the measurement of some low abundance constituents of breath. Recent developments in the design of SIFT-MS instruments have increased the ion precursor count rates. It is, however, unclear as to how these advances will affect instrument sensitivity for breath analysis. Standard gases were prepared by adding known quantities of compounds present at zero or very low levels in breath (xylene and toluene) to either humidified bottled air or actual human breath. These were then analysed by SIFT-MS to calculate the limits of detection for each compound under conditions which mimic a single breath exhalation. For xylene and toluene the limits of detection was approximately 0.5 PPBV per 10 seconds of analysis time. Results gained using this level of sensitivity suggested the presence of low levels of the compounds indole and methylindole in human alveolar and static oral air, although further studies ...Continue Reading

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Citations

Apr 8, 2011·Journal of the American Society for Mass Spectrometry·Patrik ŠpanělDavid Smith
Sep 17, 2013·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Ibrahim A HanounehRaed A Dweik
Oct 16, 2010·Advanced Powder Technology : the International Journal of the Society of Powder Technology, Japan·Alquam Mashir, Raed A Dweik
Jul 22, 2010·Mass Spectrometry Reviews·Patrik Spaněl, David Smith
Jun 15, 2011·Experimental Physiology·Peipei WangRui Wang
Feb 27, 2010·Rapid Communications in Mass Spectrometry : RCM·Liana IachettaBrian M Ross
Nov 18, 2009·Rapid Communications in Mass Spectrometry : RCM·Brian M RossChelsea Ladouceur
Apr 1, 2014·Journal of Breath Research·David SmithJonathan Beauchamp
Mar 25, 2011·The Analyst·David Smith, Patrik Spaněl
Mar 1, 2014·European Journal of Mass Spectrometry·Patrik Spanel, David Smith
Sep 29, 2019·Chemosphere·Leticia Vitola PasettoMarie-Hélène Manero
Oct 9, 2019·Chemical Reviews·Tobias BrudererRenato Zenobi

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