Sub-retinal drusenoid deposits in human retina: organization and composition.

Experimental Eye Research
Martin RudolfC A Curcio

Abstract

We demonstrate histologically sub-retinal drusenoid debris in three aged human eyes, two of them affected by age-related maculopathy. By postmortem fundus examination, the lesions were drusen-like, i.e., they were pale spots apparently at the level of the retinal pigment epithelium (RPE). Light and electron microscopy revealed aggregations of membranous debris, the principal constituent of soft drusen, in the sub-retinal space. Immunohistochemistry and confocal microscopy confirmed the presence of molecules typically associated with drusen (positive for unesterified cholesterol, apoE, complement factor H, and vitronectin) without evidence for molecules associated with photoreceptors (lectin-binding disaccharide bridges and opsins), Müller cells (glial fibrillary acid protein and cellular retinal binding protein, CRALPB), or RPE (CRALPB). The fact that a drusenoid material, sharing some markers with conventional drusen, can occur on opposite faces of the RPE, suggests deranged polarity of normally highly vectorial processes for basolateral secretion from RPE, and that overproduction of secreted materials and direction of secretion are independently specified processes. In the future, drusenoid sub-retinal debris might be more fr...Continue Reading

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Citations

Jan 11, 2011·Biologie aujourd'hui·William RaoulFlorian Sennlaub
Sep 10, 2010·Retina·Richard F SpaideSandrine A Zweifel
Oct 7, 2010·Retina·Richard F Spaide, Christine A Curcio
Jan 6, 2012·Retina·Luiz H LimaRichard F Spaide
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Aug 27, 2013·American Journal of Ophthalmology·Sotaro OotoNagahisa Yoshimura
Aug 18, 2012·Survey of Ophthalmology·Pearse A KeaneAdnan Tufail
Oct 15, 2011·American Journal of Ophthalmology·Mee Yon LeeDon-Il Ham
Oct 10, 2009·Ophthalmology·Sandrine A ZweifelYutaka Imamura
Aug 25, 2009·Progress in Retinal and Eye Research·Christine A CurcioMartin Rudolf
Apr 2, 2014·Biomedical Optics Express·Alexander MeadwayYuhua Zhang
Mar 21, 2016·Survey of Ophthalmology·Sobha SivaprasadUNKNOWN Moorfields UCL AMD Consortium
Apr 4, 2016·Ophthalmology·Ursula GreferathErica L Fletcher
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Apr 8, 2014·Progress in Retinal and Eye Research·Irina A Pikuleva, Christine A Curcio
Jul 19, 2014·American Journal of Ophthalmology·Sritatath VongkulsiriRichard F Spaide

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