Sub-threshold signal encoding in coupled FitzHugh-Nagumo neurons

Scientific Reports
Maria Masoliver, Cristina Masoller

Abstract

Despite intensive research, the mechanisms underlying the neural code remain poorly understood. Recent work has focused on the response of a single neuron to a weak, sub-threshold periodic signal. By simulating the stochastic FitzHugh-Nagumo (FHN) model and then using a symbolic method to analyze the firing activity, preferred and infrequent spike patterns (defined by the relative timing of the spikes) were detected, whose probabilities encode information about the signal. As not individual neurons but neuronal populations are responsible for sensory coding and information transfer, a relevant question is how a second neuron, which does not perceive the signal, affects the detection and the encoding of the signal, done by the first neuron. Through simulations of two stochastic FHN neurons we show that the encoding of a sub-threshold signal in symbolic spike patterns is a plausible mechanism. The neuron that perceives the signal fires a spike train that, despite having an almost random temporal structure, has preferred and infrequent patterns which carry information about the signal. Our findings could be relevant for sensory systems composed by two noisy neurons, when only one detects a weak external input.

References

May 16, 2000·Journal of Computational Neuroscience·N Brunel
Dec 2, 2000·Physical Review. E, Statistical Physics, Plasmas, Fluids, and Related Interdisciplinary Topics·M C EguiaH D Abarbanel
Oct 23, 2001·Neural Networks : the Official Journal of the International Neural Network Society·S ThorpeR Van Rullen
Dec 12, 2001·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·R SteuerF Moss
May 15, 2002·Physical Review Letters·Christoph Bandt, Bernd Pompe
Nov 5, 2002·Nature Reviews. Neuroscience·Gilles Laurent
Nov 22, 2002·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·A M LacastaJ M Sancho
Apr 20, 2004·Physical Review Letters·Ronen SegevEshel Ben-Jacob
Aug 11, 2005·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Alexander B Neiman, David F Russell
Aug 11, 2005·Physical Review Letters·Alex RoxinDavid Hansel
Oct 26, 2005·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·R E Lee DeVilleCyrill B Muratov
Dec 31, 2008·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Ibiyinka Fuwape, Alexander B Neiman
Feb 21, 2009·Nature Reviews. Neuroscience·Rodrigo Quian Quiroga, Stefano Panzeri
Apr 28, 2009·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Farzad FarkhooiMartin P Nawrot
Jun 13, 2009·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Osvaldo A Rosso, Cristina Masoller
Jan 1, 2010·Journal of Neurophysiology·Jonathan LaudanskiChristian J Sumner
Dec 29, 2010·PLoS Computational Biology·Tilo SchwalgerBenjamin Lindner
Mar 4, 2011·Optics Express·Konstantin S KravtsovDavid Rosenbluth
Apr 23, 2011·Computers in Biology and Medicine·U ParlitzN Wessel
Jan 10, 2012·Chaos·Alexander B Neiman, David F Russell
Feb 18, 2015·Scientific Reports·Markus KantnerSerhiy Yanchuk
Aug 1, 2015·Physical Review Letters·Rami M AmroAlexander B Neiman
Jan 13, 2016·Scientific Reports·Bhavin J ShastriPaul R Prucnal
Jan 20, 2016·Scientific Reports·B RomeiraJ Javaloyes
Oct 16, 2016·Physical Review. E·José A ReinosoCristina Masoller
Jun 18, 2017·Physical Review. E·Wilhelm BraunAndré Longtin

❮ Previous
Next ❯

Citations

Dec 6, 2019·Scientific Reports·Joaquín GonzálezNicolás Rubido
Apr 20, 2019·Physical Review. E·Wilhelm Braun, André Longtin
Dec 9, 2020·Entropy·Maria Masoliver, Cristina Masoller
Feb 18, 2021·Scientific Reports·Malik Muhammad IbrahimSangil Kim

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved