Subacute (28-day) toxicity of furfural in Fischer 344 rats: a comparison of the oral and inhalation route

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
Josje H E ArtsRuud A Woutersen

Abstract

The subacute oral and inhalation toxicity of furfural vapour was studied in Fischer 344 rats to investigate whether route-to-route extrapolation could be employed to derive the limit value for inhalation exposure from oral toxicity data. Groups of 5 rats per sex were treated by gavage daily for 28 days at dose levels of 6-192 mg/kg bw/day, or exposed by inhalation to concentrations of 20-1280 mg/m3 (6 h/day, 5 days/week) or 160-1280 mg/m3 (3 h/day, 5 days/week) for 28 days. Controls received vehicle (corn oil) or were exposed to clean air. Daily oral treatment with the highest dose of furfural (initially 192 mg/kg bw/day, later reduced to 144 mg/kg bw/day and finally to 120 mg/kg bw/day) resulted in mortality, and in increases in absolute and relative kidney and liver weight in surviving females of this group. Exposure of rats by inhalation for 6 h/day, 5 days/week for 28 days induced mortality at concentrations of 640 mg/m3 and above within 1-8 days. At 640 mg/m3 (3 h/day) and at 320 mg/m3 (3 and 6 h/day) and below, however, exposure was tolerated without serious clinical effects. In contrast, histopathological nasal changes were seen even at the lowest concentration of 20 mg/m3. With increasing exposure concentration, the nas...Continue Reading

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Citations

Jan 30, 2004·Regulatory Toxicology and Pharmacology : RTP·Monique A J RennenCees De Heer
Nov 12, 2005·International Archives of Occupational and Environmental Health·Josje H E ArtsRuud A Woutersen
May 1, 2007·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·T C WangC C Lin
Nov 14, 2012·Journal of Mass Spectrometry : JMS·Andreina RicciPierluigi Giacomello
Nov 30, 2011·Analytica Chimica Acta·Jens SchubertThomas G Schulz
Oct 2, 2012·Journal of Zhejiang University. Science. B·Siti Balkis BudinOthman Hidayatulfathi
Jan 24, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·T Pérez-PalaciosI M P L V O Ferreira
Nov 15, 2018·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Daiani Cecchin FerreiraJuliane Elisa Welke
Apr 1, 2005·American Journal of Physiology. Cell Physiology·Roberto JustoMagdalena Gianotti
Jul 15, 2006·Toxicological Sciences : an Official Journal of the Society of Toxicology·Lindsay B WichersWilliam P Watkinson
Nov 13, 2013·International Journal of Food Sciences and Nutrition·Trinidad Pérez-PalaciosIsabel M P L V O Ferreira
Apr 27, 2021·Environmental Science and Pollution Research International·Ahmed AlmalkiMuhammad A Wadaan

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