Subacute brachial diplegia associated with West Nile virus myelitis

Muscle & Nerve
Sahar F Zafar, Eroboghene E Ubogu

Abstract

Brachial diplegia is a clinical term used to describe weakness restricted to the upper extremities. We report a case of brachial diplegia associated with West Nile virus infection. A 48-year-old man developed severe painless bilateral upper extremity weakness within a few weeks of a flu-like illness. Clinical examination revealed marked periscapular, shoulder girdle, and humeral muscle atrophy and bilateral scapular winging, with near symmetrical bilateral hypotonic upper extremity weakness. This was associated with clinical signs of an encephalomyelopathy without cognitive or sensory deficits. Electrophysiological studies demonstrated a subacute disorder of motor neurons, their axons or both, involving the cervical and thoracic myotomes, with ongoing denervation. Serological studies confirmed recent West Nile virus (WNV) infection. Gradual improvement occurred following conservative supportive therapies. Progressive brachial diplegia is a rare neuromuscular presentation of WNV neuroinvasive disease. This case report adds to the clinical spectrum of WNV-induced neurologic sequelae.

References

Mar 15, 2000·Muscle & Nerve·P CouratierJ M Vallat
Jul 15, 2000·Journal of Neurology, Neurosurgery, and Psychiatry·B TomikP N Leigh
Jun 16, 2001·The New England Journal of Medicine·D NashUNKNOWN 1999 West Nile Outbreak Response Working Group
Sep 25, 2002·The New England Journal of Medicine·Jonathan D GlassMark M Rich
Jun 13, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Khaldoun AlmhannaAnil Sil
Oct 9, 2003·Mayo Clinic Proceedings·Mathew L FlahertyMuhammad R Sohail
Jun 22, 2005·Journal of the Neurological Sciences·Nancy Jingyang CaoJun Li
Jul 19, 2005·Emerging Infectious Diseases·James J SejvarLyle R Petersen
Jul 26, 2005·The Journal of Infection·Mustafa SaadJonathan Moorman
Jan 18, 2006·Annual Review of Medicine·Edward B Hayes, Duane J Gubler
Aug 26, 2006·Nature Clinical Practice. Neurology·Roberta L Debiasi, Kenneth L Tyler
Jan 24, 2007·Lancet Neurology·Laura D KramerPei-Yong Shi
May 2, 2007·Annals of the New York Academy of Sciences·Nikolaos W Yiannakoulias, Lawrence W Svenson
Oct 1, 2008·Neurology·Nathan Sumner, Lyell Jones
Nov 18, 2008·Journal of Neurology, Neurosurgery, and Psychiatry·F Henning, R H Hewlett
Feb 20, 2010·Journal of Neurovirology·James J SejvarAlan C Jackson
Dec 31, 2010·The Neurologist·Kenneth C GorsonGeorge D Baquis

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Citations

Dec 17, 2015·Journal of the Neurological Sciences·Deepti VibhaS Vivekanandhan
Aug 20, 2016·Journal of the Neurological Sciences·Naomi TominagaKazutoshi Nishiyama

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