PMID: 18409540Apr 16, 2008Paper

Subacute encephalitis associated with anti-glutamate receptor antibodies: serial studies of MRI, 1H-MRS and SPECT

Rinshō shinkeigaku = Clinical neurology
Shiro YamamotoHitoshi Hara

Abstract

A 32-year-old man who had experienced fever and a pulsating headache of the right occipital region for a month and a transient left hemianopia and numbness in the left arm two weeks prior to presentation was admitted to our hospital because of a seizure. Fluid-attenuated inversion recovery and diffusion-weighted magnetic resonance imaging (MRI) showed high-intensity signals, without reduction of apparent diffusion coefficient value, in the right temporo-occipital cortices. Proton MR spectroscopy (1H-MRS) indicated a decrease in N-acetylaspartate, and single-photon emission CT (SPECT) showed hyperperfusion in the right temporo-occipital territory. An examination of the cerebrospinal fluid showed an elevation of mononuclear cells and the presence of anti-glutamate epsilon2 receptor antibodies. All abnormalities shown by these imaging techniques were normalized in the clinical course. This report suggests that MRI, 1H-MRS and SPECT studies were useful in understanding the pathogenesis of encephalitis associated with glutamate receptor antibodies.

References

Feb 22, 1996·The New England Journal of Medicine·J HincheyL R Caplan
Jul 6, 2000·European Radiology·D Türkdogan-SözüerM N Pamir
Sep 21, 2000·Neuroradiology·K M CecilG L Hedlund
Jan 6, 2001·Neuron·R YangJ O McNamara
Dec 31, 2005·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Ponnada A Narayana
Dec 13, 2006·Clinical & Developmental Immunology·Yukitoshi TakahashiTateki Fujiwara

❮ Previous
Next ❯

Citations

Jan 1, 2021·Contrast Media & Molecular Imaging·Limei LuoZucai Xu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anti-N-Methyl-D-Aspartate Receptor Encephalitis

Anti-N-Methyl-D-Aspartate (NMDA) receptor encephalitis is a form of of brain inflammation due to antibodies against NMDA receptors. Discover the latest research on anti-NMDA receptor encephalitis here.

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.