Subacute human spinal cord contusion: few lymphocytes and many macrophages

Spinal Cord
H T Chang

Abstract

Clinicopathological correlation of three cases of subacute cervical spinal cord contusions. To correlate the pathology of subacute cervical spinal cord injury (SCI) with imaging and clinical-functional studies, and to compare with findings from previous human SCI studies and animal models of SCI. Department of Pathology, SUNY-Upstate Medical University, Syracuse, NY, USA. Post mortem pathology report. The clinical, radiological, and pathological findings of three cases of subacute spinal cord contusions are described in detail. The postinjury survival periods were 15, 20, and 60 days, respectively. Extensive microglia/macrophage infiltrations without significant lymphocytes are seen in all cases. Free radical injury as assessed by immunocytochemistry for 4-hydroxynonenal and nitrotyrosine showed a labeling pattern parallel to that of the macrophage distribution at 15 days, but no significant labeling in the injury sites at 20 and 60 days. The present report, though limited in sample size, shows plenty of activated microglia/macrophages in human SCI up to 60 days postinjury. This observation not only confirms similar findings in previous studies, but also raises an intriguing question of potential interactions between these acti...Continue Reading

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Citations

Feb 3, 2011·Neurochemical Research·Rajat SandhirNancy E J Berman
Oct 30, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Kristina A KigerlPhillip G Popovich
Jun 18, 2014·Journal of Neurotrauma·Amy L Bowes, Ping K Yip
May 17, 2008·Upsala Journal of Medical Sciences·Leif AnderbergAnders Holtz
Feb 7, 2016·Neurologia i neurochirurgia polska·Jacek M KwiecienWojciech Dabrowski
Oct 17, 2013·Journal of Neuropathology and Experimental Neurology·Maja RadulovicIsobel A Scarisbrick
Apr 4, 2007·Journal of Neurochemistry·Kristina A KigerlPhillip G Popovich
Jul 21, 2015·Experimental Neurology·Randall S CarpenterPhillip G Popovich
May 10, 2011·Cell Stem Cell·Frédéric BretznerRobert M Brownstone
Jan 22, 2009·Brain Research Reviews·Claire E HulseboschSusan M Carlton
May 21, 2008·Nature Reviews. Neuroscience·Phillip G Popovich, Erin E Longbrake
Jun 22, 2010·Journal of Applied Animal Welfare Science : JAAWS·Roland C AndersonStephanie R M Zimsen
Feb 15, 2019·ACS Chemical Neuroscience·Simonetta PapaPietro Veglianese

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