PMID: 6017747Jan 1, 1967Paper

Subacute necrotizing encephalomyelopathy of infancy and childhood

Journal of Clinical Pathology
D Yashon, J A Jane

Abstract

Subacute necrotizing encephalomyelopathy appears to be a distinct pathological entity occurring in infancy and childhood. The neurological manifestations are diverse but the course is one of progressive deterioration. The aetiology is not known and no treatment is available. Histologically the lesion is characterized by multiple areas of necrosis and is remarkable because of a lack of glial or small cell reaction. There is a predilection for the brain-stem but the entire neuraxis may be involved. The mammillary bodies are generally spared. Capillary proliferation and status spongiosus are seen either separately or more commonly in combination. Areas may be found in which no neural tissue is spared or a nucleus may selectively be involved with sparing of adjacent white matter, or occasionally only white matter is involved. In this account the twenty-first, twenty-second and twenty-third cases, one of which had a lesion in the mammillary body, are reported. Possible aetiological mechanisms are discussed.

References

Sep 1, 1954·The Journal of Pediatrics·I FEIGIN, A WOLF
Sep 1, 1962·Neurology·M I TOM, N B REWCASTLE
Jan 1, 1964·Archives of Neurology·F PLUM, E C ALVORD
Aug 1, 1951·Journal of Neurology, Neurosurgery, and Psychiatry·D LEIGH
Apr 1, 1949·Journal of Neuropathology and Experimental Neurology·R RICHTER
Sep 1, 1938·Archives of Disease in Childhood·W J Verhaart
Jul 1, 1944·Journal of Neurology, Neurosurgery, and Psychiatry·A Meyer

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Citations

May 1, 1986·Human Genetics·E D AdickesW G Sanger
May 1, 1986·Journal of Neurology, Neurosurgery, and Psychiatry·C D MarsdenS Nimri
Jan 1, 1973·Journal of the Neurological Sciences·A Leviton, F H Gilles
Jan 8, 2016·Pediatric Radiology·Eliana BonfanteRoy F Riascos
Jan 1, 1987·Clinical Neurology and Neurosurgery·P M van ErvenW Ruitenbeek
Feb 1, 1970·Archives of Disease in Childhood·A D DayanL Crome
Jul 1, 1968·The Journal of Pathology and Bacteriology·A H CameronB S Wood
May 1, 1992·Neurosurgery·D L Johnson, R E Erickson
Jan 1, 1972·Virchows Archiv. A: Pathology. Pathologische Anatomie·K AtermanM Lee
Aug 1, 1970·Developmental Medicine and Child Neurology·R B DavidH Okazaki
Jan 1, 1971·Acta Neuropathologica·E Farkas-BargetonH E Brissaud
Aug 1, 1970·Developmental Medicine and Child Neurology·S KamoshitaY Fukuyama

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