Subacute oral toxicity investigation of selenium nanoparticles and selenite in rats

Drug and Chemical Toxicology
Niels HadrupAlicja Mortensen

Abstract

Selenium (Se) nanoparticles have been proposed as food supplements. However, the particle formulation may exert unexpected toxicity. The aim was therefore to compare toxicity of low doses of Se nanoparticles and the dissolved, ionized Se species selenite. Female rats were dosed orally for 28 d with either: 0.05, 0.5, or 4 mg Se/kg body weight (bw)/day as 20 nm Se nanoparticles or 0.05 or 0.5 mg Se/kg bw/day as sodium selenite. Male rats were dosed 4 mg Se/kg bw/day as Se nanoparticles. Body weight and clinical appearance were recorded throughout the experiment. At necropsy, blood samples were taken for hematological and clinical chemistry analyses; organ weights were recorded. At the high-dose of Se nanoparticles, overt toxicity occurred and the female animals had to be euthanized prematurely, whereas the male animals were reduced in dose. At all doses of Se nanoparticles and at 0.5 mg Se/kg bw/day as selenite, a lower body weight gain as compared to vehicle occurred. Relative liver weight was increased for both Se formulations at 0.5 mg Se/kg bw/day. Creatinine clearance and urinary pH were affected in some Se dosed groups. There were no effects among dosed groups on brain neurotransmitters or on hematological parameters compa...Continue Reading

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Citations

May 18, 2020·Antioxidants·Jeffrey M StolwijkYousef Zakharia
Jul 2, 2020·International Journal of Environmental Research and Public Health·Aleksandra ZielińskaEliana B Souto
Jan 1, 2019·Nanoscale Horizons : the Home for Rapid Reports of Exceptional Significance in Nanoscience and Nanotechnolgy·Anisha AnandChih-Ching Huang
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Mar 7, 2021·Pharmaceutics·Dhireshan Singh, Moganavelli Singh
May 24, 2021·Environmental Science and Pollution Research International·Prashanth KondaparthiSwaran Jeet Singh Flora

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