Subacute Pb exposure during development and unbaited tunnel maze performance in mice

Pharmacology, Biochemistry, and Behavior
P W StewartP Donovick

Abstract

Although research has linked chronic, low-level Pb exposure to behavioral and cognitive changes in humans and animals, far less is known about the effects of transient, subchronic Pb exposure during early postnatal development. The need to understand such effects is underscored by the possibility that subchronic Pb exposure may not produce chronically elevated blood-Pb levels, but may produce long-term behavioral changes. To test this hypothesis, we investigated the effect of low-level Pb exposure on unbaited tunnel maze performance in Binghamton Heterogeneous Stock mice. Mice were either nontreated or given subchronic sodium acetate, 5, 10, or 25 mg/kg Pb acetate intragastrically on postnatal (PN) days 6, 9, 12, 15, and 18. No further Pb exposures were given after postnatal day 18. Blood-Pb measurements were taken from selected mice on PN 18, 19, 23, 28, and 38. On PN 38-42, all mice were individually tested in an unbaited tunnel maze under nondeprived conditions. Locomotor activity, exploration, and experience-dependent changes in cul-de-sac entries were recorded. Although Pb did not affect bodyweight and blood-Pb levels were below 10 microg/dl at the time of behavioral testing, a history of low-level preweaning Pb exposure c...Continue Reading

References

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Citations

Jul 2, 2003·Neurotoxicity Research·Carla Marchetti
Apr 12, 2000·Neurotoxicology and Teratology·H GaravanB J Strupp

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