PMID: 2915058Feb 1, 1989

Subacute radiation dermatitis: a histologic imitator of acute cutaneous graft-versus-host disease

Journal of the American Academy of Dermatology
P E LeBoit

Abstract

The histopathologic changes of radiation dermatitis have been classified either as early effects (necrotic keratinocytes, fibrin thrombi, and hemorrhage) or as late effects (vacuolar changes at the dermal-epidermal junction, atypical radiation fibroblasts, and fibrosis). Two patients, one exposed to radiation therapeutically and one accidentally, are described. Skin biopsy specimens showed an interface dermatitis characterized by numerous dyskeratotic epidermal cells with lymphocytes in close apposition (satellite cell necrosis); that is, the epidermal changes were similar to those in acute graft-versus-host disease. Because recipients of bone marrow transplants frequently receive total body irradiation as part of their preparatory regimen, the ability of radiation to cause persistent epidermal changes similar to those in acute graft-versus-host disease could complicate the interpretation of posttransplant skin biopsy specimens.

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Citations

Jul 9, 1994·Lancet·B J VermeerW E Fibbe
Oct 28, 1998·The American Journal of Dermatopathology·M G FlemingS Kohler
Apr 30, 2002·The American Journal of Dermatopathology·J A CarlsonAndrzej Slominski
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Apr 20, 2013·The American Journal of Dermatopathology·Margot S PetersNneka I Comfere
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Jul 29, 2008·Human Pathology·Noreen WalshMichael Reardon
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Feb 14, 2012·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Ning LiDavid Myerson
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Nov 23, 2019·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Wanqi ZhuHanxi Zhao
Nov 22, 2016·Journal of Cutaneous Pathology·Laura G PruittPaul B Googe
May 13, 2017·Cardiovascular and Interventional Radiology·Werner JaschkeGabriel Bartal
Sep 28, 2002·Transplantation·Shaun M KunisakiDavid H Sachs

Related Concepts

Acute Disease
Dermatitis
Differential Diagnosis
Graft-vs-Host Disease
Immunocytochemistry
Phosphorus Radioisotopes
Radiation Syndrome
Radiotherapy, Targeted
Skin
Dermatologic Disorders

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