Subacute sclerosing panencephalitis: a case with fulminant course after ACTH

Pediatric Neurology
Gul SerdarogluSarenur Tutuncuoglu

Abstract

We report a 24-month-old male who developed rapidly progressive subacute sclerosing panencephalitis 17 months after measles infection. This patient had a history of measles infection at the age of 7 months and manifested acute encephalitis 1 month later. Developmental delay observed after encephalitis began to improve after a few months. His control electroencephalogram was normal at the age of 14 months. He was admitted to the hospital with flexor spasms and sudden head drops at the age of 24 months. His electroencephalogram revealed slow waves in the posterior regions of the brain. Vigabatrin was begun; his seizures increased with vigabatrin, and adrenocorticotropic hormone was added to the therapy. After five doses of adrenocorticotropic hormone, his clinical findings deteriorated rapidly. His second electroencephalogram revealed periodic discharges synchronized with myoclonias. He was diagnosed as having subacute sclerosing panencephalitis on the basis of clinical and laboratory findings. He lapsed into a vegetative state within a week and died at the age of 25 months. We report this rapidly progressive case to emphasize the importance of recognition of subacute sclerosing panencephalitis before applying steroids in childre...Continue Reading

References

Oct 1, 1992·International Journal of Epidemiology·C MillerK Harbert
Jan 1, 1996·The Journal of Allergy and Clinical Immunology·L M SchwiebertL A Schwiebert
Feb 24, 1999·Pediatric Neurology·Y SawaishiG Takada
Aug 13, 2002·European Journal of Pediatrics·Dounia CruzadoCharles-Antoine Haenggeli

❮ Previous
Next ❯

Citations

Mar 13, 2016·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·Arushi Gahlot SainiPratibha Singhi
Jun 3, 2011·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·Sébastien LebonPierre-Yves Jeannet
May 11, 2011·Pediatric Neurology·Ronly Har-EvenTzvy Bistritzer
Oct 18, 2014·Journal of Clinical Neurology·Rukmini Mridula KandadaiSundaram Challa
Mar 28, 2012·Expert Review of Neurotherapeutics·Burak TatliMeral Ozmen
Nov 19, 2014·Evidence-based Child Health : a Cochrane Review Journal·Susan J McDonaldPeter S Morris
Feb 9, 2020·Current Neurology and Neuroscience Reports·Marc C Patterson
Aug 14, 2021·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·Tanya LamMing Lim

❮ Previous
Next ❯

Related Concepts

Related Feeds

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.

Acute Hemorrhagic Leukoencephalitis

Acute hemorrhagic leukoencephalitis is a rare form of acute disseminated encephalomyelitis characterized by acute inflammation in the brain and spinal cord that causes demyelination and bleeding. It is often fatal, although treatment with immunosuppressives and plasma exchange can be helpful. Find the latest research on acute hemorrhagic leukoencephalitis here.