Subacute sclerosing panencephalitis in children: prevalence in South China

Pediatric Neurology
Patrick IpKwok-Yin Chan

Abstract

This investigation reports the prevalence and clinical profile of subacute sclerosing panencephalitis in two developed cities of southern China. A territory-wide survey was conducted to identify all subacute sclerosing panencephalitis cases diagnosed during 1988-2002 in Hong Kong and Macau. Altogether, 10 cases (male:female = 7:3) were identified of whom six were still alive. The prevalence rate of subacute sclerosing panencephalitis in Hong Kong and Macau in 2002 was 1 per million total population or 5.5 per million children. The mean age of presentation was 9.4 years (range = 4-14 years). Presenting features included myoclonus (60%), deterioration in school performance (30%), and transient visual impairment (10%). The clinical course was highly variable. Most had subacute course, but two deteriorated rapidly and died within 6 months. Seven children had measles infection, and the majority of infection (86%) occurred during the world measles epidemic in 1988. The mean interval between measles infection and onset of subacute sclerosing panencephalitis was 6.5 years (range = 3-11 years). There has been an increasing trend of subacute sclerosing panencephalitis in southern China after the measles outbreak in 1988. Active surveilla...Continue Reading

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Citations

Jun 28, 2011·Médecine et maladies infectieuses·C BironF Raffi
Aug 5, 2008·Lancet·Edward Ho Chung WongPatrick K Kwan
Dec 21, 2007·Arquivos de neuro-psiquiatria·Marcelo Maroco CruzeiroGláucio Mendes Franco
Nov 27, 2007·International Journal of Epidemiology·H CampbellE Miller
May 3, 2005·Current Opinion in Infectious Diseases·David Elliman, Nitu Sengupta

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