Subacute toxicity of polychlorinated naphthalenes and their effect on cytochrome P-450

Ecotoxicology and Environmental Safety
Anna KilanowiczAdam Daragó

Abstract

The aim of the study was to investigate the subacute toxicity of a polychlorinated naphthalene (PCN) mixture and its effect on cytochrome P-450 levels in rats. The animals were administered PCNs intragastrically in repeated daily doses of 1, 10, and 100 mg/kg. The animals were dissected after 7, 14, or 21 doses. Doses of 10 and 100 mg/kg induced a significant decrease in the body weight at all time points of the experiment compared with the control group. The exposure to PCNs increased both the level of total cytochrome P-450 and the activity of CYP 1A at the same time points. In the groups of rats given PCNs in doses of 10 and 100 mg/kg, an evident dose- and time-dependent increase in malondialdehyde (MDA) level was observed throughout the experiment. The correlation between the increased MDA and decreased glutathione (GSH) levels in the liver was also observed.

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Citations

Sep 26, 2015·Reproductive Toxicology·Anna KilanowiczKrystyna Sitarek
Sep 29, 2009·Ecotoxicology and Environmental Safety·Anna Kilanowicz, Malgorzata Skrzypinska-Gawrysiak
Mar 14, 2012·International Journal of Occupational Medicine and Environmental Health·Anna KilanowiczMałgorzata Skrzypińska-Gawrysiak
Nov 3, 2010·Ecotoxicology and Environmental Safety·Anna KilanowiczAndrzej Sapota
Mar 6, 2012·Neurotoxicology·Anna KilanowiczWieslaw Szymczak
Jan 21, 2015·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Tineke SlootwegMarkus Liebig
Sep 17, 2014·Journal of Environmental Science and Health. Part C, Environmental Carcinogenesis & Ecotoxicology Reviews·Jerzy FalandyszMartin Rose
May 18, 2010·Journal of Environmental Monitoring : JEM·Xiaohui PanGan Zhang
Sep 27, 2018·Environmental Pollution·Joanna StragierowiczAnna Kilanowicz

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