Subacute toxicity of polychlorinated naphthalenes and their effect on cytochrome P-450
Abstract
The aim of the study was to investigate the subacute toxicity of a polychlorinated naphthalene (PCN) mixture and its effect on cytochrome P-450 levels in rats. The animals were administered PCNs intragastrically in repeated daily doses of 1, 10, and 100 mg/kg. The animals were dissected after 7, 14, or 21 doses. Doses of 10 and 100 mg/kg induced a significant decrease in the body weight at all time points of the experiment compared with the control group. The exposure to PCNs increased both the level of total cytochrome P-450 and the activity of CYP 1A at the same time points. In the groups of rats given PCNs in doses of 10 and 100 mg/kg, an evident dose- and time-dependent increase in malondialdehyde (MDA) level was observed throughout the experiment. The correlation between the increased MDA and decreased glutathione (GSH) levels in the liver was also observed.
References
Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent
Polychlorinated naphthalenes and other organochlorine contaminants in human adipose and liver tissue
Polychlorinated naphthalenes in animal aquatic species and human exposure through the diet: a review
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