Subacute toxicity study of the ethanolic extract of Mesua ferrea (L.) flowers in rats.

Drug and Chemical Toxicology
Pallavi ShirsatSachin Tembhurne

Abstract

Mesua ferrea Linn. is used traditionally in India and South East Asian countries as an antiseptic, antidote and a brain tonic. Recent pharmacological studies on the plant have highlighted M. ferrea to be a rich source of secondary metabolites, with proven therapeutic applications. Since the toxicity of a plant following repeated exposure is of higher clinical significance, the present investigation was conducted to establish the subacute toxicity profile of the ethanolic extract of Mesua ferrea flowers (MFE). The study was conducted in accordance with the OECD Guideline 407, wherein MFE was administered orally to groups of male and female rats (n = 5/group/sex) at the doses of 100, 500 and 1000 mg/kg, over a period of 28 days. Repeated administration of MFE had no adverse effect on the growth rate and hematological parameters of the animals. There were no changes in the biochemical parameters, except for a slight decrease in the CHOL (total cholesterol) levels, and an increase in the levels of AST (aspartate aminotransferase) and ALT (alanine aminotransferase), at the highest dose. The latter corroborated with the histopathological findings exhibiting mild lymphocytic infiltration and hepatocyte degeneration observed in the liv...Continue Reading

References

Sep 20, 2005·Journal of Ethnopharmacology·Nunthawun UawonggulSakda Daduang
Jul 31, 2007·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Shashi K Ramaiah
Aug 19, 2007·Indian Journal of Pediatrics·B R Thapa, Anuj Walia
Feb 19, 2008·Journal of Ethnopharmacology·J H Costa-SilvaA G Wanderley
Aug 6, 2009·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·G D SinghR K Johri
Aug 31, 2010·Journal of Ethnopharmacology·Adel TahraouiBadiâa Lyoussi
Oct 12, 2011·Journal of Ethnopharmacology·Sunil S JalalpureAmol S Shah
May 29, 2012·International Immunopharmacology·Manoj Kumar ChaharK P Manohara
Dec 24, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Sylvin Benjamin AtebaDieudonné Njamen
Jan 5, 2014·Journal of Ethnopharmacology·Maxwell I EzejaIsaac U Asuzu
Apr 8, 2014·Gastroenterology·Mercedes Robles-DiazUNKNOWN Safer and Faster Evidence-based Translation Consortium
Nov 12, 2014·Journal of Toxicology·Oluyomi Stephen Adeyemi, Bukola Temitope Orekoya
Oct 13, 2015·Journal of Ethnopharmacology·Fengjin LiHongbin Xiao
Jul 19, 2016·Journal of Ethnopharmacology·Mutiat B IbrahimOlukemi A Odukoya
Mar 16, 2017·Journal of Ethnopharmacology·Juliana Calil BrondaniMelânia Palermo Manfron
Apr 7, 2017·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A D Ricart
Mar 8, 2016·Medical Sciences : Open Access Journal·Idris BelloMohd Zaini Asmawi
May 31, 2019·Drug and Chemical Toxicology·Parshuram Nivrutti Shendge, Sateesh Belemkar

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.