Subarachnoid hemorrhage enhances the expression of TDP-43 in the brain of experimental rats and human subjects

Experimental and Therapeutic Medicine
Tibiao HeFei Liu

Abstract

The transactive response DNA-binding protein of 43 (TDP-43) may be involved in neurodegenerative disease and in the response to brain injury; however, alterations in the expression of TDP-43 following subarachnoid hemorrhage (SAH) require further investigation. The present study reported a notable elevation in the expression of TDP-43 within the cerebrospinal fluid (CSF) of patients with aneurysmal SAH and increased brain expression of TDP-43 in a rat model of SAH. The TDP-43 protein and a derivative migrated at 43 and 24 kDa, respectively, as observed via the immunoblotting of concentrated CSF samples obtained from patients with SAH; no signal was detected in the CSF from healthy controls. SAH in rats was induced by intravascular suture puncture. The expression levels of TDP-43 in rat cortical lysates following SAH were increased at 0.5 h, peaked at 48 h and remained significantly elevated at 72 h post-injury, compared with sham controls. TDP-43 immunolabeling indication localization within neurons, astrocytes and microglia in the experimental rats. Collectively, the findings of the present study indicated the early involvement of TDP-43 in the brain in response to SAH, and that expression levels of TDP-43 in the CSF may serve...Continue Reading

References

Sep 18, 2007·Journal of Neuroscience Methods·Takashi SugawaraJohn H Zhang
Jul 16, 2008·Experimental Neurology·Ken TakataFrederick W Lombard
Nov 20, 2008·Journal of Neuropathology and Experimental Neurology·Claudia SchwabPatrick L McGeer
Jul 3, 2010·Stroke; a Journal of Cerebral Circulation·Timour Al-KhindiTom A Schweizer
Dec 4, 2010·Amyotrophic Lateral Sclerosis : Official Publication of the World Federation of Neurology Research Group on Motor Neuron Diseases·Yu-Ichi NotoSatoshi Kuwabara
Dec 1, 2011·Nature Reviews. Neuroscience·Edward B LeeJohn Q Trojanowski
Mar 13, 2012·Brain Research·Colleen M DeweyGang Yu
Mar 30, 2013·Stroke; a Journal of Cerebral Circulation·Junhao YanJohn H Zhang
Jan 16, 2014·Neurobiology of Disease·Vineeta Bhasker TripathiSarah Guthrie
Jun 5, 2014·Stroke; a Journal of Cerebral Circulation·Yusuke EgashiraGuohua Xi
Jun 12, 2014·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Zhihui YangKevin K W Wang
Jul 22, 2014·Glia·Robert F FernPeter K Stys
Jun 28, 2015·Brain : a Journal of Neurology·Terrance T KummerDavid L Brody
Oct 9, 2015·PloS One·Ana Sofia CorreiaJean-Pierre Julien
Jan 29, 2016·Neuropathology and Applied Neurobiology·T OnozatoK Oyanagi
Feb 27, 2016·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Akira IshiguroAkira Ishihama
Sep 13, 2016·Immunology and Cell Biology·Lisa ZondlerJochen H Weishaupt
Sep 30, 2016·Brain : a Journal of Neurology·Yohei IguchiJean-Pierre Julien
Mar 25, 2017·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·María M Leal-LasarteCintia Roodveldt
Nov 17, 2017·Scientific Reports·Josiah J HerzogSuzanne Paradis

❮ Previous
Next ❯

Citations

Aug 8, 2021·International Journal of Molecular Sciences·Fiona BrightYazi D Ke

❮ Previous
Next ❯

Methods Mentioned

BETA
fluorescence microscopy
Infrared Imaging
ELISA

Software Mentioned

GraphPad
GraphPad Prism

Related Concepts

Related Feeds

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.

Astrocytes & Neurodegeneration

Astrocytes are important for the health and function of the central nervous system. When these cells stop functioning properly, either through gain of function or loss of homeostatic controls, neurodegenerative diseases can occur. Here is the latest research on astrocytes and neurodegeneration.

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.