Subarachnoid Hemorrhage Severely Impairs Brain Parenchymal Cerebrospinal Fluid Circulation in Nonhuman Primate

Stroke; a Journal of Cerebral Circulation
Romain GoulayThomas Gaberel

Abstract

Subarachnoid hemorrhage (SAH) is a devastating form of stroke with neurological outcomes dependent on the occurrence of delayed cerebral ischemia. It has been shown in rodents that some of the mechanisms leading to delayed cerebral ischemia are related to a decreased circulation of the cerebrospinal fluid (CSF) within the brain parenchyma. Here, we evaluated the cerebral circulation of the CSF in a nonhuman primate in physiological condition and after SAH. We first evaluated in physiological condition the circulation of the brain CSF inMacacafacicularis, using magnetic resonance imaging of the temporal DOTA-Gd distribution after its injection into the CSF. Then, animals were subjected to a minimally invasive SAH before an MRI evaluation of the impact of SAH on the brain parenchymal CSF circulation. We first demonstrate that the CSF actively penetrates the brain parenchyma. Two hours after injection, almost the entire brain is labeled by DOTA-Gd. We also show that our model of SAH in nonhuman primate displays the characteristics of SAH in humans and leads to a dramatic impairment of the brain parenchymal circulation of the CSF. The CSF actively penetrates within the brain parenchyma in the gyrencephalic brain, as described for t...Continue Reading

References

Jun 26, 2004·Stroke; a Journal of Cerebral Circulation·Alejandro A RabinsteinEelco F M Wijdicks
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Citations

Mar 19, 2019·Anesthesia and Analgesia·Helene BenvenisteNora D Volkow
Jul 25, 2019·Stroke and Vascular Neurology·Quan Jiang
May 31, 2020·Diagnostics·Jasleen KaurQuan Jiang
Sep 11, 2019·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Skylar E JohnsonManus J Donahue
Jan 30, 2018·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Antoine P FournierFabian Docagne
Oct 25, 2017·Current Atherosclerosis Reports·Joseph R Geraghty, Fernando D Testai
Jul 6, 2020·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Di CaoJun Hua
Oct 21, 2018·Fluids and Barriers of the CNS·Stephen B Hladky, Margery A Barrand
Mar 14, 2020·Current Neurology and Neuroscience Reports·Ayushe A Sharma, Jerzy P Szaflarski
Oct 5, 2019·CNS Neuroscience & Therapeutics·Badih J DaouAditya S Pandey
Oct 2, 2020·Journal of Applied Physiology·Helene BenvenisteAllen Tannenbaum
Jan 15, 2021·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Hoyee WanR Loch Macdonald
Nov 3, 2020·Frontiers in Cellular and Infection Microbiology·Caitlin TiceDianne Langford
Feb 23, 2021·Reviews in the Neurosciences·Galina YankovaAndrey Tulupov
Mar 2, 2021·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Nicholas Burdon BèchetIben Lundgaard
Mar 7, 2021·International Journal of Molecular Sciences·Baptiste BalançaAnne-Claire Lukaszewicz
May 6, 2021·Physiological Reviews·Martin Kaag RasmussenMaiken Nedergaard
Jul 17, 2021·Parkinsonism & Related Disorders·Colin D McKnightDaniel O Claassen
Jul 27, 2021·Frontiers in Neuroanatomy·Jasleen KaurQuan Jiang
Jul 27, 2021·Frontiers in Aging Neuroscience·Tao LvXiaohua Zhang
Jul 22, 2021·BMC Veterinary Research·Nagesh C ShanbhagIben Lundgaard
Jun 24, 2021·Journal of Neurochemistry·Jiru ZhouHua Feng
Nov 29, 2020·Neuroscience·Helene BenvenisteNora D Volkow
Oct 26, 2018·Lancet Neurology·Martin Kaag RasmussenMaiken Nedergaard
Nov 23, 2021·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Yuanjian FangJohn H Zhang

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