PMID: 6113270Jun 1, 1981Paper

Subcellular and perisynaptic distribution of rat brain aldehyde dehydrogenase activity

Journal of Neurochemistry
T KoivulaM Koivusalo

Abstract

The nuclear mitochondrial and synaptosomal fractions of rat brain were each found to contain some 25-30% of the total aldehyde dehydrogenase activity. The cytoplasmic fraction had a very low total aldehyde dehydrogenase activity. There were differences in the distribution of the activity when different aldehydes were used as substrates, suggesting the presence of isoenzymes in the various subcellular compartments. When rats were treated intracisternally with 6-hydroxydopamine there was no change in brain aldehyde dehydrogenase activity, although the noradrenaline content and the activities of tyrosine hydroxylase and dopamine-beta-hydroxylase were markedly decreased. Treatment with 6-hydroxydopamine also had no significant effect on the aldehyde dehydrogenase activity in retinal homogenates. The results suggest that the aldehyde dehydrogenase activity in rat brain is predominantly outside the catecholaminergic nerve terminals.

References

May 1, 1975·Journal of Neurochemistry·B TabakoffW O Boggan
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Aug 1, 1973·European Journal of Biochemistry·M M Ris, J P von Wartburg
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Citations

Jan 1, 1990·Pharmacology & Therapeutics·H W Goedde, D P Agarwal
Jan 1, 1981·Progress in Neuro-psychopharmacology·F GarcinC Radouco-Thomas
Mar 5, 2003·Journal of Neurochemistry·Tonya C MurphyMatthew J Picklo
Sep 1, 1983·Journal of Neurochemistry·H Cao DanhP Dostert
Jan 1, 1984·Journal of Neurochemistry·H Weiner, B Ardelt
Apr 1, 1982·Journal of Neurochemistry·K Inoue, K O Lindros
Dec 1, 1992·Alcoholism, Clinical and Experimental Research·S M ZimatkinK O Lindros

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