PMID: 240768Aug 1, 1975

Subcellular distribution and properties of kynurenine pyruvate transaminase in rat kidney

Hoppe-Seyler's Zeitschrift für physiologische Chemie
T NoguchiR Kido


Kynurenine transaminase activity in rat kidney was found in both the mitochondrial and supernatant fractions. These fractions contained (a) kynurenine pyruvate transaminase, which showed a preference for pyruvate as amino acceptor, and had a pH optimum between 8.0 and 8.5, and (b) kynurenine 2-oxoglutarate transaminase, with a preference for 2-oxoglutarate and a pH optimum between 6.0 and 6.5. The apparent Km value of the former enzyme for L-kynurenine was much lower than that of the latter enzyme.

Related Concepts

Alpha Ketoglutarate
Pyruvate Measurement
Mitochondria, Liver
Aminotransferase Activity
Ketoglutaric Acids

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