PMID: 2116308Jul 20, 1990Paper

Subcellular distribution of lipoxygenase products in rabbit reticulocyte membranes

European Journal of Biochemistry
H KühnR Wiesner

Abstract

Mitochondrial membranes and plasma membranes of rabbit reticulocytes contain oxygenated polyenoic fatty acids such as (9Z,11E)-(13S)-13-hydroxy-9,11-octadecadienoic acid, 9S and 9R isomers of (10E,12Z)-9-hydroxy-10,12-octadecadienoic acid and their all-E isomers. Furthermore (5Z,8Z,11Z,13E)-(15S)-15-hydroxy-5,8,11,13-icosa tetraenoic acid, 9- and 13-oxooctadecadienoic acid were detected as minor products. The chemical structure of these products has been identified by co-chromatography with authentic standards, by ultraviolet and infrared spectroscopy, and by gas chromatography/mass spectrometry of the native compounds and their hydrogenated derivatives. The oxygenated fatty acids originate most probably from the intracellular action of the erythroid arachidonate 15-lipoxygenase. In membranes of the mature erythrocyte only small amounts of hydroxy fatty acids were detected. Young peripheral reticulocytes contain more oxygenated polyenoic fatty acids in their membranes than older cells. In mixed cell populations, about 85% of the lipoxygenase products were found esterified to the membrane ester lipids, whereas 15% were associated as free hydroxy fatty acids with the membranes. The hydroxy fatty acid content of the mitochondrial ...Continue Reading

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Citations

Mar 29, 1996·Chemistry and Physics of Lipids·M Herold, G Spiteller
Jul 30, 1996·Chemistry and Physics of Lipids·A DuddaF Kobelt
Jan 1, 1996·Free Radical Biology & Medicine·K SchnurrT Schewe
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