Subcellular distribution of selenium in the liver from rats fed selenium from fish: selenocystine and inorganic selenite

Annals of Nutrition & Metabolism
O RingdalK Julshamn

Abstract

Four groups of rats of a normal selenium status were given different selenium compounds during a long-term feeding experiment (28 days). The selenium supplementations (per kg diet) were sodium selenite (1 mg), selenocystine (2 mg), and two different concentration levels of selenium from fish (0.1 and 1 mg). Differential pelleting of liver homogenates demonstrated that selenium was present in all the subcellular fractions, with a recovery of 55-60% in the cytosols. Gel permeation high-performance liquid chromatography of the cytosol fractions demonstrated the presence of protein-bound selenium at a molecular weight of 70,000 daltons. The subcellular distributions as well as the protein binding of selenium in the cytosols were identical in all dietary groups. This indicates a similar long-term liver metabolism of the four selenium compounds tested in the rat.

Citations

Jan 1, 1988·The International Journal of Biochemistry·G Hocman
Dec 21, 2002·International Journal of Cancer. Journal International Du Cancer·Tara M VogtSusan T Mayne
May 26, 2001·Annual Review of Nutrition·D Behne, A Kyriakopoulos
Jan 1, 1988·Nutrition Research Reviews·J K Chesters, J R Arthur

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