Subcellular Localization and Dynamics of the Bcl-2 Family of Proteins

Frontiers in Cell and Developmental Biology
Nikolay PopgeorgievGermain Gillet

Abstract

Bcl-2 family proteins are recognized as major regulators of the mitochondrial pathway of apoptosis. They control the mitochondrial outer membrane permeabilization (MOMP) by directly localizing to this organelle. Further investigations demonstrated that Bcl-2 related proteins are also found in other intracellular compartments such as the endoplasmic reticulum, the Golgi apparatus, the nucleus and the peroxisomes. At the level of these organelles, Bcl-2 family proteins not only regulate MOMP in a remote fashion but also participate in major cellular processes including calcium homeostasis, cell cycle control and cell migration. With the advances of live cell imaging techniques and the generation of fluorescent recombinant proteins, it became clear that the distribution of Bcl-2 proteins inside the cell is a dynamic process which is profoundly affected by changes in the cellular microenvironment. Here, we describe the current knowledge related to the subcellular distribution of the Bcl-2 family of proteins and further emphasize on the emerging concept that this highly dynamic process is critical for cell fate determination.

References

Oct 15, 1993·Biochemical and Biophysical Research Communications·M NakaiT Endo
Nov 1, 1996·American Journal of Clinical Pathology·J F MosnierS Boucheron
Apr 15, 1997·Proceedings of the National Academy of Sciences of the United States of America·Y T HsuR J Youle
Jan 7, 1998·The Journal of Cell Biology·K G WolterR J Youle
Mar 9, 2002·The Journal of Biological Chemistry·Marc GermainGordon C Shore
Jan 3, 2003·Nature Cell Biology·Michiko Shirane, Keiichi I Nakayama
Jan 8, 2003·The Journal of Cell Biology·Thomas KaufmannChristoph Borner
Jan 17, 2003·The Journal of Biological Chemistry·Pierre-François CartronFrançois M Vallette
Jul 9, 2003·The Journal of Cell Biology·Wei-Xing ZongCraig B Thompson
Jul 11, 2003·The EMBO Journal·Leonie QuinnHelena Richardson
Jul 26, 2003·Science·Emily H Y ChengStanley J Korsmeyer
May 8, 2004·The EMBO Journal·Seon-Yong JeongRichard J Youle
Aug 27, 2005·Cell·Sandra S ZinkelStanley J Korsmeyer
Sep 24, 2005·Nature Cell Biology·Carl WhiteJ Kevin Foskett
Feb 18, 2006·American Journal of Physiology. Gastrointestinal and Liver Physiology·Ariel E FeldsteinGregory J Gores
Nov 9, 2006·The Journal of Biological Chemistry·Bryce Patrick Portier, Giulio Taglialatela
Mar 21, 2007·Nature Cell Biology·Xiaobo WangGail E Sonenshein
Jun 9, 2007·The Journal of Biological Chemistry·Emine ErFrançois M Vallette
Dec 22, 2007·Nature Reviews. Molecular Cell Biology·Richard J Youle, Andreas Strasser
Dec 6, 2008·Biochimica Et Biophysica Acta·Yi-Ping RongClark W Distelhorst
Mar 10, 2009·Cell Biology International·Nadia BarbouleFlorence Larminat
Jul 14, 2010·Current Biology : CB·Emélie BraschiHeidi M McBride
Jan 20, 2011·Journal of Cell Science·Juan Garcia ValeroAbdel Aouacheria

❮ Previous
Next ❯

Citations

Jan 19, 2019·Nature Reviews. Molecular Cell Biology·Rumani SinghKristopher Sarosiek
Sep 11, 2019·Cold Spring Harbor Perspectives in Biology·Hristina IvanovaGeert Bultynck
Apr 15, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Shalini PandeySudipta Basu
Apr 24, 2020·Journal of Cellular Physiology·Suzanne EstaphanEnas Ahmed Mohamed
Aug 28, 2020·EMBO Reports·Geeta RaoPriyabrata Mukherjee
Dec 28, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mei-Fen ChenI-Min Liu
Jan 17, 2020·Biomolecules·Suresh BanjaraMarc Kvansakul
Dec 31, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Chongjie YaoShimin Liu
May 20, 2020·Frontiers in Cell and Developmental Biology·Binghu LiLiangming Liu
Nov 6, 2018·Frontiers in Pharmacology·Gaia FaveroRita Rezzani
Nov 28, 2019·Cell Biology International·Pooja ChauhanShyamal K Goswami
May 1, 2019·Bioscience Reports·Hong-Wei CuiXiu-Lan Su
May 1, 2020·Cell Death Discovery·Liora LindenboimReuven Stein
Oct 6, 2020·Frontiers in Cell and Developmental Biology·Qiang HeWei Lu
Nov 29, 2020·Nature Communications·Maria Jesús García-MurriaLuis Martínez-Gil
Jul 30, 2019·International Journal of Biological Macromolecules·Meenakshi SharmaKrishna Mohan Poluri
Jun 9, 2020·Redox Biology·Jamelle A BrownScott W Ballinger
Dec 18, 2020·Cell Death and Differentiation·Federico LucantoniJochen H M Prehn
Feb 17, 2021·Cell Death & Disease·Lisenn LalierFrançois M Vallette
Feb 11, 2021·Cell Death Discovery·Liora LindenboimReuven Stein
Nov 21, 2020·Current Genomics·Rahul Semwal, Pritish Kumar Varadwaj
Apr 3, 2021·Biochimica Et Biophysica Acta. Molecular Cell Research·Fernanda O LemosJan B Parys
May 1, 2021·International Journal of Molecular Sciences·Jordan L MorrisNikolay Popgeorgiev
May 1, 2021·International Journal of Molecular Sciences·Akandé Rouchidane EyitayoStéphen Manon
May 21, 2021·Biochimica Et Biophysica Acta. Reviews on Cancer·Linlin ZhangXiangxuan Zhao
Jul 3, 2021·Cancers·Luiza HandschuhKrzysztof Lewandowski
Sep 9, 2021·Proceedings of the National Academy of Sciences of the United States of America·Victor Vasquez-MontesAlexey S Ladokhin
Oct 13, 2021·Journal of Zhejiang University. Science. B·Xing DUXiuying Pei

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Methods Mentioned

BETA
nuclear translocation
Fluorescence
confocal microscopy

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